Document Detail

Thyroid disease in pregnancy.
MedLine Citation:
PMID:  22115167     Owner:  NLM     Status:  MEDLINE    
Thyroid diseases are common in women of childbearing age and it is well known that untreated thyroid disturbances result in an increased rate of adverse events, particularly miscarriage, preterm birth and gestational hypertension. Furthermore, thyroid autoimmunity per se seems to be associated with complications such as miscarriage and preterm delivery. While strong evidence clearly demonstrates that overt dysfunctions (hyper- or hypothyroidism) have deleterious effects on pregnancy, subclinical disease, namely subclinical hypothyroidism, has still to be conclusively defined as a risk factor for adverse outcomes. Additionally, other conditions, such as isolated hypothyroxinemia and thyroid autoimmunity in euthyroidism, are still clouded with uncertainty regarding the need for substitutive treatment.
Roberto Negro; Jorge Hector Mestman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Best practice & research. Clinical endocrinology & metabolism     Volume:  25     ISSN:  1878-1594     ISO Abbreviation:  Best Pract. Res. Clin. Endocrinol. Metab.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-25     Completed Date:  2012-03-19     Revised Date:  2012-11-07    
Medline Journal Info:
Nlm Unique ID:  101120682     Medline TA:  Best Pract Res Clin Endocrinol Metab     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  927-43     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Division of Endocrinology, "V. Fazzi" Hospital, Lecce, Italy.
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MeSH Terms
Abnormalities, Drug-Induced
Antithyroid Agents / administration & dosage,  adverse effects,  therapeutic use
Autoimmunity / immunology
Hyperemesis Gravidarum / diagnosis
Hyperthyroidism / diagnosis*,  drug therapy
Hypothyroidism / complications*,  drug therapy
Infant, Newborn
Infant, Newborn, Diseases / etiology
Mass Screening
Pregnancy Complications / etiology*
Pregnancy Outcome
Pregnancy Trimesters
Thyroid Diseases / complications*
Thyroid Gland / immunology
Thyrotropin / blood
Thyroxine / blood,  therapeutic use
Reg. No./Substance:
0/Antithyroid Agents; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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