Document Detail

Thyroid disease and the heart.
MedLine Citation:
PMID:  17923583     Owner:  NLM     Status:  MEDLINE    
The cardiovascular signs and symptoms of thyroid disease are some of the most profound and clinically relevant findings that accompany both hyperthyroidism and hypothyroidism. On the basis of the understanding of the cellular mechanisms of thyroid hormone action on the heart and cardiovascular system, it is possible to explain the changes in cardiac output, cardiac contractility, blood pressure, vascular resistance, and rhythm disturbances that result from thyroid dysfunction. The importance of the recognition of the effects of thyroid disease on the heart also derives from the observation that restoration of normal thyroid function most often reverses the abnormal cardiovascular hemodynamics. In the present review, we discuss the appropriate thyroid function tests to establish a suspected diagnosis as well as the treatment modalities necessary to restore patients to a euthyroid state. We also review the alterations in thyroid hormone metabolism that accompany chronic congestive heart failure and the approach to the management of patients with amiodarone-induced alterations in thyroid function tests.
Irwin Klein; Sara Danzi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Circulation     Volume:  116     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-09     Completed Date:  2007-11-13     Revised Date:  2008-02-25    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1725-35     Citation Subset:  AIM; IM    
Department of Medicine and the Feinstein Institute for Medical Research, North Shore University Hospital, 350 Community Dr, Manhasset, NY 11030, USA.
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MeSH Terms
Cardiovascular Diseases / etiology*,  physiopathology
Gene Expression Regulation
Heart / physiopathology*
Myocytes, Cardiac / physiology
Renin-Angiotensin System
Thyroid Diseases / physiopathology*
Thyroid Function Tests
Thyroid Hormones / physiology
Grant Support
Reg. No./Substance:
0/Thyroid Hormones
Erratum In:
Circulation. 2008 Jan 22;117(3):e18

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