|Thyroid cancer incidence patterns in Sao Paulo, Brazil, and the U.S. SEER program, 1997-2008.|
|PMID: 23410185 Owner: NLM Status: MEDLINE|
|BACKGROUND: Thyroid cancer incidence has risen steadily over the last few decades in most of the developed world, but information on incidence trends in developing countries is limited. Sao Paulo, Brazil, has one of the highest rates of thyroid cancer worldwide, higher than in the United States. We examined thyroid cancer incidence patterns using data from the Sao Paulo Cancer Registry (SPCR) in Brazil and the National Cancer Institute's Surveillance Epidemiology End Results (SEER) program in the United States.
METHODS: Data on thyroid cancer cases diagnosed during 1997-2008 were obtained from SPCR (n=15,892) and SEER (n=42,717). Age-adjusted and age-specific rates were calculated by sex and histology and temporal patterns were compared between the two populations.
RESULTS: Overall incidence rates increased over time in both populations and were higher in Sao Paulo than in the United States among females (SPCR/SEER incidence rate ratio [IRR]=1.65) and males (IRR=1.23). Papillary was the most common histology in both populations, followed by follicular and medullary carcinomas. Incidence rates by histology were consistently higher in Sao Paulo than in the United States, with the greatest differences for follicular (IRR=2.44) and medullary (IRR=3.29) carcinomas among females. The overall female/male IRR was higher in Sao Paulo (IRR=4.17) than in SEER (IRR=3.10) and did not change over time. Papillary rates rose over time more rapidly in Sao Paulo (annual percentage change=10.3% among females and 9.6% among males) than in the United States (6.9% and 5.7%, respectively). Regardless of sex, rates rose faster among younger people (<50 years) in Sao Paulo, but among older people (≥50 years) in the United States. The papillary to follicular carcinoma ratio rose from <3 to >8 among both Sao Paulo males and females, in contrast to increases from 9 to 12 and from 6 to 7 among U.S.males and females, respectively.
CONCLUSIONS: Increased diagnostic activity may be contributing to the notable rise in incidence, mainly for papillary type, in both populations, but it is not likely to be the only reason. Differences in iodine nutrition status between Sao Paulo and the U.S. SEER population might have affected the observed incidence patterns.
|Lene H S Veiga; Gila Neta; Briseis Aschebrook-Kilfoy; Elaine Ron; Susan S Devesa|
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|Type: Comparative Study; Journal Article; Research Support, N.I.H., Intramural Date: 2013-05-28|
|Title: Thyroid : official journal of the American Thyroid Association Volume: 23 ISSN: 1557-9077 ISO Abbreviation: Thyroid Publication Date: 2013 Jun|
|Created Date: 2013-06-07 Completed Date: 2014-01-28 Revised Date: 2014-06-03|
Medline Journal Info:
|Nlm Unique ID: 9104317 Medline TA: Thyroid Country: United States|
|Languages: eng Pagination: 748-57 Citation Subset: IM|
|APA/MLA Format Download EndNote Download BibTex|
Brazil / epidemiology
Carcinoma / epidemiology, ethnology, etiology
Diet / adverse effects, ethnology
Iodine / administration & dosage, deficiency
Thyroid Neoplasms / epidemiology*, ethnology, etiology
United States / epidemiology
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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