Document Detail


Thyroid cancer in Belarus post-Chernobyl: improved detection or increased incidence?
MedLine Citation:
PMID:  7941769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is debate on whether the reported increase in the number of cases of childhood thyroid cancer in Belarus is real and attributable to radiation released following the Chernobyl nuclear accident, or rather an artefact due to incorrect histological diagnosis, more complete case reporting and mass screening of children after the accident. We have scrutinised the histological slides of 120 (75%) of the 160 cases reported among children aged up to 15 years to the Belarus tumour registry from 1986 to 1992 and examined time trends and geographical patterns in incidence and tumour characteristics. Incidence based on reported cases increased from 0.041 per 100,000 in 1986 to 2.548 in 1992. Carcinoma was confirmed in 94% of reviewed tumours. Except for one medullary carcinoma all histologies were of the papillary type. Most of the tumours had spread beyond the organ capsule and measured over 10 mm in diameter. There was a weak and statistically non-significant trend (p = 0.19) towards smaller tumours in the later years. The proportion of cases with lymphnode or distant metastasis remained unchanged. Incidence based on histologically confirmed cases was highest adjacent and to the west and north of Chernobyl, matching best estimates of iodine-131 contamination. Our data thus strongly suggest that the observed increase is real but more data are needed in order to assess the impact of mass screening and to clarify the possible association with radiation released at Chernobyl in 1986.
Authors:
T Abelin; J I Averkin; M Egger; B Egloff; A W Furmanchuk; F Gurtner; J A Korotkevich; A Marx; I I Matveyenko; A E Okeanov
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Sozial- und Präventivmedizin     Volume:  39     ISSN:  0303-8408     ISO Abbreviation:  Soz Praventivmed     Publication Date:  1994  
Date Detail:
Created Date:  1994-10-27     Completed Date:  1994-10-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7502479     Medline TA:  Soz Praventivmed     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  189-97     Citation Subset:  IM    
Affiliation:
Department of Social and Preventive Medicine, University of Berne.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Byelarus / epidemiology
Carcinoma, Papillary / epidemiology*,  etiology
Child
Child, Preschool
Confidence Intervals
Female
Humans
Incidence
Infant
Male
Neoplasms, Radiation-Induced / epidemiology*
Power Plants*
Radioactive Hazard Release*
Thyroid Neoplasms / epidemiology*,  etiology
Ukraine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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