Document Detail

Thyroid autoregulation. Inhibitory effects of iodinated derivatives of arachidonic acid on iodine metabolism.
MedLine Citation:
PMID:  3141976     Owner:  NLM     Status:  MEDLINE    
Thyroid autoregulation has been linked to an organified iodocompound. Since several iodolipids are produced by the gland their possible role in thyroid autoregulation was examined. The following pure synthetic compounds were prepared: 1) 14-iodo-15-hydroxy-5,8,11-eicosatrienoic acid (I-OH-A); 2) its omega lactone (IL-omega); 3) 5-hydroxy-6-iodo-8,11,14-eicosatrienoic acid delta lactone (IL-delta). Their action on iodine metabolism was studied. Iodine uptake was measured in calf thyroid slices. At 10(-4)M I-OH-A caused a 64% decrease in the T/M ratio, while IL-omega inhibited it by 36% and IL-delta was without effect. At 10(-5)M the inhibition was 44% for I-OH-A and 19% for IL-omega, while T3 was without action. A possible isotopic dilution effect was excluded, and no change in iodine efflux was observed. The inhibition by I-OH-A of iodide uptake was observed after only 15 min preincubation. This compound also decreased 125I accumulation in rats. In calf thyroid slices, I-OH-A at 10(-4)M, inhibited PB125I formation by 80%, IL-omega by 62% and IL-delta by 37%. T3 and arachidonic acid were without action. I-OH-A also caused a dose-dependent inhibition of TSH-stimulated iodide organification. The present results demonstrate, for the first time, that iodinated derivatives of arachidonic acid inhibit thyroid function and mimic the effect of iodide on thyroid autoregulation.
G D Chazenbalk; R M Valsecchi; L Krawiec; G Burton; G J Juvenal; E Monteagudo; H A Chester; M A Pisarev
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prostaglandins     Volume:  36     ISSN:  0090-6980     ISO Abbreviation:  Prostaglandins     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-12-22     Completed Date:  1988-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0320271     Medline TA:  Prostaglandins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  163-72     Citation Subset:  IM    
Division Bioquimica Nuclear, Gerencia de Radioisótopos, Buenos Aires, Argentina.
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MeSH Terms
Arachidonic Acid
Arachidonic Acids / pharmacology*
Iodine / pharmacokinetics*
Rats, Inbred Strains
Thyroid Gland / physiology*
Reg. No./Substance:
0/Arachidonic Acids; 506-32-1/Arachidonic Acid; 7553-56-2/Iodine

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