Document Detail

Thyroid autoimmunity and miscarriage.
MedLine Citation:
PMID:  19121990     Owner:  NLM     Status:  MEDLINE    
The relation of thyroid autoimmunity to miscarriage is an important issue that has attracted the interest of many investigators. A number of papers have been published so far, which include healthy women, women with recurrent miscarriage and those undergoing assisted reproductive techniques. Most studies have shown a significant positive association between the presence of thyroid autoantibodies and miscarriage rate. It is of interest that women with high titers do not show a higher miscarriage rate when compared with women having low titers, although, there is no general agreement on this issue. There are three possible explanations for the assumed association of thyroid autoimmunity with miscarriage: 1) pregnancy loss is an epiphenomenon and not a direct effect of the thyroid autoantibodies, the presence of thyroid autoantibodies reflecting a generalized activation of the immune system; 2) delayed conception from the presence of thyroid autoantibodies; hence, when women with thyroid autoimmunity become pregnant, face a higher risk of miscarriage because of older age; and 3) the pregnancy loss is secondary to a subtle deficiency in thyroid hormone concentrations or a lower capacity of the thyroid to adequately adapt to the demands of pregnancy.
Athina Kaprara; Gerasimos E Krassas
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Hormones (Athens, Greece)     Volume:  7     ISSN:  1109-3099     ISO Abbreviation:  Hormones (Athens)     Publication Date:    2008 Oct-Dec
Date Detail:
Created Date:  2009-01-05     Completed Date:  2009-02-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101142469     Medline TA:  Hormones (Athens)     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  294-302     Citation Subset:  IM    
Department of Endocrinology, Diabetes and Metabolism, "Panagia" General Hospital, Thessaloniki, Greece.
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MeSH Terms
Abortion, Spontaneous / etiology*,  immunology
Autoantibodies / immunology
Autoimmune Diseases / complications*
Autoimmunity / drug effects,  physiology*
Thyroid Diseases / complications*,  immunology
Thyroxine / administration & dosage,  pharmacology
Reg. No./Substance:
0/Autoantibodies; 7488-70-2/Thyroxine

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