| Thyroid autoimmunity and environment. | |
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MedLine Citation:
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PMID: 19343619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Autoimmune thyroid disorders (AITDs) are the result of a complex interplay between genetic and environmental factors, the former account for about 70-80% of liability to develop AITDs. However, at least 20-30% is contributed by environmental factors, which include certainly smoking (at least for Graves' disease and orbitopathy), probably stress, iodine and selenium intake, several drugs, irradiation, pollutants, viral and bacterial infections, allergy, pregnancy, and post-partum. Evidence for the intervention of these factors is often limited, and the mechanisms whereby environmental factors may concur to the onset of AITDs are in many instances unclear. Nevertheless, gene-environment interaction seems a fundamental process for the occurrence of AITDs. |
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Authors:
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M L Tanda; E Piantanida; A Lai; V Lombardi; I Dalle Mule; L Liparulo; N Pariani; L Bartalena |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-04-02 |
Journal Detail:
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Title: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme Volume: 41 ISSN: 1439-4286 ISO Abbreviation: Horm. Metab. Res. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-10 Completed Date: 2009-08-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0177722 Medline TA: Horm Metab Res Country: Germany |
Other Details:
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Languages: eng Pagination: 436-42 Citation Subset: IM |
Affiliation:
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Department of Clinical Medicine, University of Insubria, Varese, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoimmune Diseases / etiology*, immunology Environment* Female Humans Immunity Male Smoking Stress, Physiological Thyroid Diseases / etiology*, immunology |
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