Document Detail

Thyroid autoimmunity and environment.
MedLine Citation:
PMID:  19343619     Owner:  NLM     Status:  MEDLINE    
Autoimmune thyroid disorders (AITDs) are the result of a complex interplay between genetic and environmental factors, the former account for about 70-80% of liability to develop AITDs. However, at least 20-30% is contributed by environmental factors, which include certainly smoking (at least for Graves' disease and orbitopathy), probably stress, iodine and selenium intake, several drugs, irradiation, pollutants, viral and bacterial infections, allergy, pregnancy, and post-partum. Evidence for the intervention of these factors is often limited, and the mechanisms whereby environmental factors may concur to the onset of AITDs are in many instances unclear. Nevertheless, gene-environment interaction seems a fundamental process for the occurrence of AITDs.
M L Tanda; E Piantanida; A Lai; V Lombardi; I Dalle Mule; L Liparulo; N Pariani; L Bartalena
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-04-02
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  41     ISSN:  1439-4286     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-10     Completed Date:  2009-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  436-42     Citation Subset:  IM    
Department of Clinical Medicine, University of Insubria, Varese, Italy.
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MeSH Terms
Autoimmune Diseases / etiology*,  immunology
Stress, Physiological
Thyroid Diseases / etiology*,  immunology

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