Document Detail

Thyroid-associated orbitopathy developed during hormone replacement therapy.
MedLine Citation:
PMID:  11453868     Owner:  NLM     Status:  MEDLINE    
Thyroid-associated orbitopathy (TAO) developed in relation to estrogen combined with progesterone therapy has not been reported previously. We report a case of a 56-year-old postmenopausal woman who during estrogen/progesterone treatment developed signs and symptoms of orbitopathy. The patient had no previous history of autoimmune- or thyroid disorders. The initial eye symptoms disappeared after withdrawal of hormone replacement therapy. Five years later estrogen/progesterone treatment was re-instituted. The patient had relapse of orbitopathy. The hormones were discontinued and the eye symptoms disappeared again. This suggests that estrogen and/or progesterone could be of some pathogenetic importance in the induction of orbitopathy
C G Øgard; C Øgard; T P Almdal
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta ophthalmologica Scandinavica     Volume:  79     ISSN:  1395-3907     ISO Abbreviation:  Acta Ophthalmol Scand     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-07-16     Completed Date:  2001-09-13     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  9507578     Medline TA:  Acta Ophthalmol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  426-7     Citation Subset:  IM    
Department of Endocrinology and Department of Ophthalmology, Herlev Hospital, University of Copenhagen, Denmark.
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MeSH Terms
Drug Therapy, Combination
Estrogens / adverse effects*
Graves Disease / chemically induced*
Hormone Replacement Therapy / adverse effects*
Middle Aged
Orbital Diseases / chemically induced*
Progesterone / adverse effects*
Reg. No./Substance:
0/Estrogens; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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