Document Detail


Thyroid-type solid cell nests in struma ovarii.
MedLine Citation:
PMID:  20034983     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Solid cell nests (SCNs) of the thyroid are single or multiple foci of solid and/or cystic clusters of squamoid cells (main cells) with a minor proportion of C-cells, found in the normal thyroid. The SCNs have also been reported in the heart as an ultimobranchial heterotopia. Here, the authors describe a case of thyroid-type SCNs associated with struma ovarii. Main cells were positive for simple and stratified epithelial-type cytokeratins, carcinoembryonic antigen, carbohydrate antigen 19.9, p63, bcl-2, and galectin-3. The neuroendocrine cell population was positive for chromogranin A and synaptophysin but negative for calcitonin, suggesting a common ancestor cell capable of dual differentiation toward thyroid follicular cells and hindgut-type endocrine cells. The existence of thyroid-type SCNs in struma ovarii could be easily understood by considering the struma ovarii as a teratoma; at the same time, these findings also support the idea of a close histogenetic link between the main cells of SCNs and thyroid tissue.
Authors:
José Cameselle-Teijeiro; Nuria Caramés; Alfredo Romero-Rojas; Rosa Reyes-Santías; Magalí Piso-Neira; Ignacio Bernabeu; Ihab Abdulkader
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Publication Detail:
Type:  Journal Article     Date:  2009-12-24
Journal Detail:
Title:  International journal of surgical pathology     Volume:  19     ISSN:  1940-2465     ISO Abbreviation:  Int. J. Surg. Pathol.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-11-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9314927     Medline TA:  Int J Surg Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  627-31     Citation Subset:  IM    
Affiliation:
1Hospital Clínico Universitario, Galician Health Service, University of Santiago de Compostela, Galicia, Spain.
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