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Thyroid Transcription Factor-1 is a Specific Marker of Benign but Not Malignant Feline Lung Tumours.
MedLine Citation:
PMID:  24813152     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Feline lung tumours are currently subclassified according to the criteria of the World Health Organisation, but this scheme contains overlap in the tumour phenotype. The aims of the present study were to re-evaluate the histological features of feline lung tumours and to correlate these with expression of the markers thyroid transcription factor (TTF)-1 and Ki67. TTF-1 was found to be a highly specific marker for neoplastic and non-neoplastic lung tissue and thyroid tissue, but was expressed only weakly in invasive lung tumours. A combined semiquantitative score for Ki67 and TTF-1 expression correlated well with differentiation and invasive behaviour of the tumours and may thus be of potential value for evaluation of feline lung tumours.
Authors:
A Kujawa; P Olias; A Böttcher; R Klopfleisch
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-20
Journal Detail:
Title:  Journal of comparative pathology     Volume:  -     ISSN:  1532-3129     ISO Abbreviation:  J. Comp. Pathol.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-5-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0102444     Medline TA:  J Comp Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ltd. All rights reserved.
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