| Thyroid-Related Autoantibodies in Tunisian Patients with Type 1 Diabetes. | |
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MedLine Citation:
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PMID: 22149460 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aim. To evaluate, retrospectively, the frequency of antithyroid antibodies (ATA) in patients with type 1 diabetes (T1D). Materials and methods. Antithyroperoxidase antibodies (TPO-Ab), antithyroglobulin antibodies (TG-Ab), and antithyroid-stimulating hormone receptor antibodies (TSHR-Ab) were determined by enzyme-linked immunosorbent assay. Sera of 312 patients (166 children and 146 adults) with T1D were analyzed. Sera of 276 healthy subjects (87 children and 189 blood donors) served as controls. Results. Out of 312 patients with T1D, 44 (14%) had ATA (TPO-Ab or TG-Ab or TSHR-Ab). The frequency of ATA in patients with T1D was significantly higher than in the control group (14% vs. 2.8%; p < 10(-5)). ATA were significantly more frequent in adult patients with T1D than in the blood donor group (20% vs. 1.6%; p < 10(-8)). The frequency of ATA in adult patients was significantly higher than in pediatric patients (20% vs. 9%; p = 0.006). The frequency of TPO-Ab and TG-Ab was significantly higher in patients with T1D than in the control group (13.5% vs. 2%; p < 10(-8) and 7% vs. 2.2%, p = 0.008), respectively. Out of 312 patients with T1D, only one had TSHR-Ab. The simultaneous presence of three autoantibodies was found in one patient with T1D. Conclusion. ATA were frequent in patients with T1D. Serological screening of autoimmune thyroid disease is suggested in patients with T1D. |
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Authors:
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Wahiba Sakly; Amani Mankaï; Achouak Achour; Yosra Thabet; Mohamed Ouertani; Lamia Boughammoura; Abdelaziz Harbi; Laarbi Chaieb; Mohamed Taher Sfar; Ibtissem Ghedira |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-9 |
Journal Detail:
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Title: Endocrine research Volume: - ISSN: 1532-4206 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8408548 Medline TA: Endocr Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Research Unit (03/UR/07-02), Faculty of Pharmacy , Monastir , Tunisia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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