| Thyroid Incidentaloma identified by (18) F-fluorodeoxyglucose Positron Emission Tomography with CT (FDG-PET/CT): clinical and pathological relevance. | |
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MedLine Citation:
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PMID: 21575027 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: the percentage of patients with thyroid cancer incidentally diagnosed during a (18) F-fluorodeoxyglucose Positron Emission Tomography with CT (FDG-PET/CT) for non-thyroid diseases ranges between 26% and 50%. Design: retrospective assessment of the clinical and pathological features of thyroid incidentalomas at FDG-PET/CT, aiming to identify potential predictors of malignancy. Patients: 52 patients with incidental thyroid uptake at FDG-PET/CT were retrospectively included [38 W, age 64.1±12.5 yrs (mean±SD)]. An arbitrary cut-off level of 5.0 for the "maximum standardized uptake value" (SUV max) was chosen to differentiate benign from malignant tumours. Complete thyroid function, neck ultrasonography (US) features, cyto-histological results were reported for all cases. Results: in our institution the prevalence of incidental thyroid (18) F-fluorodeoxyglucose ((18) F-FDG) uptake was nearly 1.76%. The prevalence of focal uptake correlated with greater risk of malignancy (p<0.01). In particular, the euthyroidism (p<0.003) and a SUV max >5.0 (p<0.0001) were associated with the diagnosis of thyroid cancer. Diffusely increased FDG-PET/CT uptake in the thyroid was related to benign conditions. Conclusions: the presence of focal uptake with high SUV max and euthyroidism correlate with high likelihood of malignancy. Performing a neck US would have to be recommended in all patients with euthyroidism and an incidental FDG-PET/CT focal thyroid uptake. We do not suggest to use FDG-PET/CT as screening tool for thyroid cancer in the general population, both because of its high cost and the low incidence of thyroid incidentaloma at FDG-PET/CT. |
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Authors:
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L Pagano; L Samàx; F Morani; F Prodam; M Rudoni; R Boldorini; G Valente; P Marzullo; R Baldelli; M Appetecchia; C Isidoro; G Aimaretti |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-16 |
Journal Detail:
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Title: Clinical endocrinology Volume: - ISSN: 1365-2265 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Blackwell Publishing Ltd. |
Affiliation:
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Endocrinology, Department of Clinical and Experimental Medicine, "University of Piemonte Orientale A. Avogadro", Novara, Italy. Molecular Pathology, Department of Medical Science, "University of Piemonte Orientale A. Avogadro", Novara, Italy. Nuclear Medicine, AOU "Maggiore della Carità", Novara, Italy. Department of Medical Sciences, "University of Piemonte Orientale A. Avogadro", Novara, Italy. Laboratory of Pathology, Department of Clinical and Experimental Medicine, "University of Piemonte Orientale A. Avogadro", Novara, Italy. Endocrinology Unit, Regina Elena Cancer Institute-IFO, Rome, Italy. |
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