| Thyroid hormone-induced cardiac mechano growth factor expression depends on beating activity. | |
| | |
MedLine Citation:
|
PMID: 20032059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The mechano growth factor (MGF), a splice variant of the IGF-I gene, was first discovered in mechanically overloaded skeletal muscle and was shown to play an important role in proliferation of muscle stem cells. Since then, the presence and effects of MGF have been demonstrated in other tissues. MGF has been shown to act neuroprotectively during brain ischemia, and pretreatment with MGF before myocardial infarction improves cardiac function. Because MGF plays a permissive role in exercise-induced skeletal muscle hypertrophy, we hypothesize that MGF is commonly involved in cardiac hypertrophy. To investigate the regulation of MGF expression in heart, mice were treated with thyroid hormone (T(3)) for 12 d to induce physiological cardiac hypertrophy. MGF mRNA expression was specifically increased in midregions of the septum and left ventricular wall. Interestingly, MGF expression strongly correlated with the increased or decreased beating frequency of hyperthyroid and hypothyroid hearts. To further investigate the mechanically dependent induction of MGF, neonatal rat cardiomyocytes were isolated and exposed to T(3). Upon T(3) treatment, cardiomyocytes increased both contractile activity measured as beats per minute and MGF as well as IGF-IEa mRNA expression. Importantly, when cardiomyocytes were contractile arrested by KCl, simultaneous exposure to T(3) prevented the up-regulation of MGF, whereas IGF-IEa was still induced. These studies demonstrated that MGF but not IGF-IEa expression is dependent on beating activity. These findings suggest that MGF is specifically stimulated by mechanical loading of the heart to mediate the hypertrophic response to thyroid hormone. |
| | |
Authors:
|
Miriam van Dijk-Ottens; Ingrid H C Vos; Peter W A Cornelissen; Alain de Bruin; Maria E Everts |
Related Documents
:
|
21186079 - Mir-185 targets rhoa and cdc42 expression and inhibits the proliferation potential of h... 17446459 - Regulation of ncx1 gene expression in the normal and hypertrophic heart. 12672819 - The small gtp-binding protein rac1 induces cardiac myocyte hypertrophy through the acti... 18566129 - Aldosterone induces cardiotrophin-1 expression in hl-1 adult cardiomyocytes. 17706969 - Preferential existence of death-inducing proteins in the human cardiomyopathic left ven... 12623879 - Reengineering inducible cardiac-specific transgenesis with an attenuated myosin heavy c... 8793109 - Binding preferences of the pou domain protein brain-4: implications for autoregulation. 7543649 - Effect of hexachlorocyclohexane isomers on calmodulin mrna expression in the central ne... 19420289 - Increased prolyl 4-hydroxylase expression and differential regulation of hypoxia-induci... |
Publication Detail:
|
Type: Journal Article Date: 2009-12-23 |
Journal Detail:
|
Title: Endocrinology Volume: 151 ISSN: 1945-7170 ISO Abbreviation: Endocrinology Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2010-01-26 Completed Date: 2010-02-26 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
|
Languages: eng Pagination: 830-8 Citation Subset: AIM; IM |
Affiliation:
|
Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80.158, NL-3508 TD Utrecht, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alternative Splicing Animals Animals, Newborn Genetic Variation Hyperthyroidism / chemically induced, physiopathology Hypothyroidism / chemically induced, physiopathology Insulin-Like Growth Factor I / genetics*, pharmacology, physiology Mice Mice, Inbred C57BL Muscle, Skeletal / drug effects, physiology Myocytes, Cardiac / physiology Physical Conditioning, Animal Polymerase Chain Reaction Propylthiouracil / pharmacology RNA / genetics RNA, Messenger / genetics Rats Rats, Wistar Thyroid Gland / physiology Triiodothyronine / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/RNA, Messenger; 0/mechano-growth factor, mouse; 51-52-5/Propylthiouracil; 63231-63-0/RNA; 67763-96-6/Insulin-Like Growth Factor I; 6893-02-3/Triiodothyronine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: REDD1 is a major target of testosterone action in preventing dexamethasone-induced muscle loss.
Next Document: Minireview: Delivering the Code: Polyplex Carriers for Deoxyribonucleic Acid and Ribonucleic Acid In...