| Thyroid Function and Prevalent and Incident Metabolic Syndrome in Older Adults: The Health, Aging, and Body Composition Study. | |
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MedLine Citation:
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PMID: 22187968 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: Both subclinical hypothyroidism and the metabolic syndrome have been associated with increased risk of coronary heart disease events. It is unknown if the prevalence and incidence of metabolic syndrome is higher as TSH levels increase, or in individuals with subclinical hypothyroidism. We sought to determine the association between thyroid function and the prevalence and incidence of the metabolic syndrome in a cohort of older adults. Design: Data was analyzed from the Health, Aging, and Body Composition Study, a prospective cohort of 3,075 community-dwelling US adults. Participants: 2,119 participants with measured TSH and data on metabolic syndrome components were included in the analysis. Measurements: TSH was measured by immunoassay. Metabolic syndrome was defined per revised ATP III criteria. Results: At baseline, 684 participants met criteria for metabolic syndrome. At 6yr follow-up, incident metabolic syndrome developed in 239 individuals. In fully adjusted models, each unit increase in TSH was associated with a 3% increase in the odds of prevalent metabolic syndrome (OR 1.03, 95% CI 1.01-1.06, p=0.02), and the association was stronger for TSH within the normal range (OR 1.16, 95% CI 1.03 - 1.30, p=0.02). Subclinical hypothyroidism with a TSH>10mIU/L was significantly associated with increased odds of prevalent metabolic syndrome (OR 2.3, 95% CI 1.0-5.0, p=0.04); the odds of incident MetS was similar (OR 2.2), but the confidence interval was wide (0.6 - 7.5). Conclusions: Higher TSH levels and subclinical hypothyroidism with a TSH>10 mIU/L are associated with increased odds of prevalent but not incident metabolic syndrome. © 2011 Blackwell Publishing Ltd. |
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Authors:
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Avantika C Waring; Nicolas Rodondi; Stephanie Harrison; Alka M Kanaya; Eleanor M Simonsick; Iva Miljkovic; Suzanne Satterfield; Anne B Newman; Douglas C Bauer; |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-20 |
Journal Detail:
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Title: Clinical endocrinology Volume: - ISSN: 1365-2265 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Departments of Medicine Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94143 Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California 94120 Clinical Research Branch, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892 Division of Geriatric Medicine and Gerontology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260 Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163. |
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