| Thyroid function and 3,3'-diiodothyronine sulfate cross-reactive substance (compound w) in maternal hyperthyroidism with antithyroid treatment. | |
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MedLine Citation:
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PMID: 20713348 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective: To test whether the serial measurement of maternal levels of compound W, a 3,3'-diiodothyronine sulfate cross-reactive substance, can serve as a potential indicator of fetal thyroid function in pregnant women receiving antithyroid medication.Methods: Compound W was measured repeatedly in serum of pregnant women with hyperthyroidism treated with antithyroid medication. Free thyroxine levels of mothers and serum thyroid-stimulating hormone levels of 1-day-old neonates were analyzed by local clinical or state laboratories.Results: Use of minimal antithyroid medication impaired the progressive increase of compound W seen in euthyroid mothers during pregnancy. At term, depressed compound W levels in maternal serum were found in 7 of 22 pregnancies; in 1 case, maternal compound W was suppressed and newborn thyroid-stimulating hormone was elevated. Seven mothers with treated hyperthyroidism failed to show an increase in serum levels of compound W after midterm.Conclusion: Normal progression of maternal serum compound W may be an index of normal fetal thyroid development in mothers with hyperthyroidism treated with necessary antithyroid medication. |
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Authors:
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Lester Vanmiddlesworth; N Rue Vanmiddlesworth; Robert S Egerman; Andrew J Bush; Risa D Ramsey; Lucinda P Delmar; Eugene C Ho; Sing-Yung Wu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists Volume: 17 ISSN: 1934-2403 ISO Abbreviation: Endocr Pract Publication Date: 2011 Mar-Apr |
Date Detail:
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Created Date: 2011-04-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607439 Medline TA: Endocr Pract Country: United States |
Other Details:
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Languages: eng Pagination: 170-6 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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