| The Thyroid Epidemiology, Audit, and Research Study (TEARS): Morbidity in Patients with Endogenous Subclinical Hyperthyroidism. | |
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MedLine Citation:
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PMID: 21346066 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: Our objective was to investigate the long-term outcomes for patients with endogenous subclinical hyperthyroidism (SH). Design: Population record-linkage technology was used retrospectively to identify patients with SH and hospital admissions from January 1, 1993, to December 31, 2009. Patients: All Tayside residents over 18 yr old with at least two serum TSH measurements below the reference range for at least 4 months apart and normal free T(4)/total T(4) and normal total T(3) concentrations at baseline were included as potential cases. Using a unique patient identifier, data linkage enabled a cohort of SH cases to be identified from biochemistry, prescription, admission, and radioactive iodine treatment records matched to five comparators from the general population. Outcome Measures: The association between endogenous SH and cardiovascular disease, fracture, dysrhythmia, dementia, and cancer was assessed. Results: Compared with the reference population, SH was associated with an increased risk of nonfatal cardiovascular morbidity, osteoporotic fracture, dysrhythmia, and dementia, with adjusted hazard ratios (HR) of 1.39 (1.22-1.58), 1.25 (1.04-1.50), 1.65 (1.26-2.17), and 1.64 (1.20-2.25), respectively. When SH patients who developed overt hyperthyroidism during follow-up were excluded, SH patients were associated with an increased risk of cardiovascular morbidity [HR = 1.36 (1.19-1.57)], dysrhythmia [HR = 1.39 (1.02-1.90)], and dementia [HR = 1.79 (1.28-2.51)] but not fracture and cancer. Conclusion: Patients with endogenous SH have an increased risk of cardiovascular disease and dysrhythmia. There is an association with fracture and dementia that is not related to TSH concentration and therefore is less likely to be causally related. No association was found between SH and cancer. |
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Authors:
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Thenmalar Vadiveloo; Peter T Donnan; Lynda Cochrane; Graham P Leese |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-23 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: - ISSN: 1945-7197 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Dundee Epidemiology and Biostatistics Unit (T.V., P.T.D., L.C.), Division of Clinical and Population Sciences and Education, and Department of Medicine (G.P.L.), University of Dundee, Dundee, Scotland, United Kingdom. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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