Document Detail

The Thyroid Epidemiology, Audit, and Research Study (TEARS): the natural history of endogenous subclinical hyperthyroidism.
MedLine Citation:
PMID:  20926532     Owner:  NLM     Status:  In-Process    
OBJECTIVE: For patients with subclinical hyperthyroidism (SH), the objective of the study was to define the rates of progression to frank hyperthyroidism and normal thyroid function.
DESIGN: Record-linkage technology was used retrospectively to identify patients with SH in the general population of Tayside, Scotland, from January 1, 1993, to December 31, 2009.
PATIENTS: All Tayside residents with at least two measurements of TSH below the reference range for at least 4 months from baseline and normal free T(4)/total T(4) and total T(3) concentrations at baseline were included as potential cases. Using a unique patient identifier, data linkage enabled a cohort of SH cases to be identified from prescription, admission, and radioactive iodine treatment records. Cases younger than 18 yr of age were also excluded from the study.
OUTCOME MEASURES: The status of patients was investigated at 2, 5, and 7 yr after diagnosis.
RESULTS: We identified 2024 cases with SH, a prevalence of 0.63% and an incidence of 29 per 100,000 in 2008. Most SH cases without thyroid treatment remained as SH at 2 (81.8%), 5 (67.5%), and 7 yr (63.0%) after diagnosis. Few patients (0.5-0.7%) developed hyperthyroidism at 2, 5, and 7 yr. The percentage of SH cases reverting to normal increased with time: 17.2% (2 yr), 31.5% (5 yr), and 35.6% (7 yr), and this was more common in SH patients with baseline TSH between 0.1 and 0.4 mU/liter.
CONCLUSION: Very few SH patients develop frank hyperthyroidism, whereas a much larger proportion revert to normal, and many remain with SH.
Thenmalar Vadiveloo; Peter T Donnan; Lynda Cochrane; Graham P Leese
Publication Detail:
Type:  Journal Article     Date:  2010-10-06
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  96     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E1-8     Citation Subset:  AIM; IM    
Division of Clinical and Population Sciences and Education, University of Dundee, Dundee, Scotland, United Kingdom.
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MeSH Terms
Comment In:
J Clin Endocrinol Metab. 2011 Jan;96(1):59-61   [PMID:  21209045 ]

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