| The Thyroid Epidemiology, Audit, and Research Study (TEARS): the natural history of endogenous subclinical hyperthyroidism. | |
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MedLine Citation:
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PMID: 20926532 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: For patients with subclinical hyperthyroidism (SH), the objective of the study was to define the rates of progression to frank hyperthyroidism and normal thyroid function. DESIGN: Record-linkage technology was used retrospectively to identify patients with SH in the general population of Tayside, Scotland, from January 1, 1993, to December 31, 2009. PATIENTS: All Tayside residents with at least two measurements of TSH below the reference range for at least 4 months from baseline and normal free T(4)/total T(4) and total T(3) concentrations at baseline were included as potential cases. Using a unique patient identifier, data linkage enabled a cohort of SH cases to be identified from prescription, admission, and radioactive iodine treatment records. Cases younger than 18 yr of age were also excluded from the study. OUTCOME MEASURES: The status of patients was investigated at 2, 5, and 7 yr after diagnosis. RESULTS: We identified 2024 cases with SH, a prevalence of 0.63% and an incidence of 29 per 100,000 in 2008. Most SH cases without thyroid treatment remained as SH at 2 (81.8%), 5 (67.5%), and 7 yr (63.0%) after diagnosis. Few patients (0.5-0.7%) developed hyperthyroidism at 2, 5, and 7 yr. The percentage of SH cases reverting to normal increased with time: 17.2% (2 yr), 31.5% (5 yr), and 35.6% (7 yr), and this was more common in SH patients with baseline TSH between 0.1 and 0.4 mU/liter. CONCLUSION: Very few SH patients develop frank hyperthyroidism, whereas a much larger proportion revert to normal, and many remain with SH. |
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Authors:
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Thenmalar Vadiveloo; Peter T Donnan; Lynda Cochrane; Graham P Leese |
Publication Detail:
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Type: Journal Article Date: 2010-10-06 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 96 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: E1-8 Citation Subset: AIM; IM |
Affiliation:
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Division of Clinical and Population Sciences and Education, University of Dundee, Dundee, Scotland, United Kingdom. t.vadiveloo@cpse.dundee.ac.uk |
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Descriptor/Qualifier:
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| Comments/Corrections | |
Comment In:
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J Clin Endocrinol Metab. 2011 Jan;96(1):59-61
[PMID:
21209045
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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