Document Detail

Thyroid C cells of middle-aged rats treated with estradiol or calcium.
MedLine Citation:
PMID:  9541474     Owner:  NLM     Status:  MEDLINE    
The structure and function of C cells of middle-aged female rats (14-months old) treated with estradiol dipropionate (EDP), calcium (Ca) or a combination of EDP+Ca were studied. A stereological method was used to determine the volume of calcitonin (CT)-immunoreactive C cells and their nuclei, and the relative volume density and mean number of the C cells per section were calculated. Serum levels of CT, osteocalcin, parathyroid hormone (PTH), and beta-estradiol were also measured. A significant decrease in body weight of the rats treated with EDP or EDP+Ca was observed. These treatments led to a significant decrease in cellular and nuclear volumes, relative volume density, and mean number of C cells per section, in comparison with the corresponding controls. A reduction of the serum level of CT, PTH, and osteocalcin was also recorded in EDP- and EDP+Ca-treated animals. No statistically significant differences between Ca- and vehicle-injected rats, with regard to all morphometric C cell parameters and biochemical values determined, were seen. However, a conspicuous degranulation of the C cells and decreased immunoreactivity for CT in the Ca-receiving group, which could be interpreted as the signs of increased activity of these cells, were noticed. This effect of Ca was also observed in rats injected with EDP and Ca in combination, when the inhibitory effect of EDP on C cell function was less noticeable than in the group treated with EDP alone.
M Sekulić; M Lovren; V Milosević; M Mićić; L Balint-Perić
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Histochemistry and cell biology     Volume:  109     ISSN:  0948-6143     ISO Abbreviation:  Histochem. Cell Biol.     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-05-26     Completed Date:  1998-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9506663     Medline TA:  Histochem Cell Biol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  257-62     Citation Subset:  IM    
Institute für Biological Research Sinisa Stanković, Belgrade, Yugoslavia.
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MeSH Terms
Body Weight / drug effects
Calcium / pharmacology*
Estradiol / analogs & derivatives*,  pharmacology
Immunoenzyme Techniques
Rats, Wistar
Thyroid Gland / cytology,  drug effects*
Reg. No./Substance:
113-38-2/estradiol dipropionate; 50-28-2/Estradiol; 7440-70-2/Calcium

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