Document Detail

Thyroid Antibody Positivity in the First Trimester of Pregnancy Is Associated with Negative Pregnancy Outcomes.
MedLine Citation:
PMID:  21411559     Owner:  NLM     Status:  Publisher    
Context: Thyroid antibody positivity during pregnancy has been associated with adverse outcomes including spontaneous miscarriage, recurrent miscarriage, and preterm delivery. Objective: The objective of the study was to determine whether thyroid antibody positivity in the first trimester of pregnancy in euthyroid women was associated with maternal and neonatal adverse outcomes. Design: The present trial is a component of a prospective trial published in 2010 that evaluated screening for thyroid disease during pregnancy and the impact of levothyroxine therapy in women who were thyroid peroxidase positive with a TSH above 2.5 mIU/liter. The present study compared 14 maternal and neonatal adverse outcomes in 245 women who were euthyroid (TSH < 2.5 mIU/liter) and thyroid peroxidase positive in the first trimester to 3348 women who were euthyroid and thyroid peroxidase negative in the first trimester. Setting: The study was conducted in southern Italy at the ambulatory clinics of two community hospitals. Patients: The study consisted of 3593 women. Intervention: There was no intervention. Main Outcome Measures: The main outcome measures were 14 maternal and neonatal complications. Results: The main result was an increase in very preterm delivery (<34 wk gestation at delivery) [4.5 vs. 1.8%; χ(2)(df = 1) = 8.58; P = 0.003] and respiratory distress [3.3 vs. 1.2%; χ(2)(df = 1) = 7.80; P = 0.005] in women who were thyroid antibody positive. Conclusions: The present study provides further evidence of an association between thyroid antibody positivity and very preterm delivery in euthyroid women. The association with respiratory distress should be considered preliminary and awaits further study.
Roberto Negro; Alan Schwartz; Riccardo Gismondi; Andrea Tinelli; Tiziana Mangieri; Alex Stagnaro-Green
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-16
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  -     ISSN:  1945-7197     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Division of Endocrinology (R.N.), "V. Fazzi" Hospital, 73100 Lecce, Italy; Department of Medical Education, Department of Pediatrics (A.S.), University of Illinois, Chicago, Illinois 60607; Division of Obstetrics and Gynecology (R.G.), Casa di Cura "Salus", 72100 Brindisi, Italy; Division of Obstetrics and Gynecology (A.T.), and Division of Neonatology and Intensive Care Unit (T.M.), "V. Fazzi" Hospital, 73100 Lecce, Italy; and Department of Medicine, Department of Obstetrics and Gynecology (A.S.-G.), George Washington University School of Medicine and Health Sciences, Washington, D.C. 20052.
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