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Thyroglobulin synthesis of oxyphilic cells in various types of neoplastic and autoimmune thyroid diseases.
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PMID:  1698387     Owner:  NLM     Status:  MEDLINE    
To determine the content of thyroglobulin in oxyphilic cells of the thyroid, which have been considered as non-thyroglobulin producing cells, the degree of stainability of the various oxyphilic cells for thyroglobulin was compared with that of non-oxyphilic follicular cells in either same or different lesion. A total of 13 oxyphilic lesions, including three follicular adenomas containing oxyphilic cell nodules, four pure oxyphilic cell adenomas, and six Hashimoto's thyroiditis were compared with 16 of non-oxyphilic lesions such as, seven follicular adenomas, four chronic lymphocytic thyroiditis, and five Graves' disease. Many oxyphilic cells stained positively for thyroglobulin regardless of their morphologic variation, but less intensely than the usual follicular cells in follicular adenomas, chronic lymphocytic thyroiditis, and Graves' disease. The stainability of oxyphilic cells for thyroglogulin did not show any significant correlation with morphologic features, whereas in follicular adenomas, the non-oxyphilic follicular cells forming microfollicles stained less strongly for thyroglobulin than the same cells lining large mature follicles in a reproducible way. With above findings, we concluded that oxyphilic cells maintain the functional activity in terms of thyroglobulin synthesis, although the content of the thyroglobulin is less than that of non-oxyphilic colloid forming follicular cells.
T S Hwang; J S Suh; Y I Kim; S H Park; B Y Cho; C S Koh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of Korean medical science     Volume:  5     ISSN:  1011-8934     ISO Abbreviation:  J. Korean Med. Sci.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-11-09     Completed Date:  1990-11-09     Revised Date:  2011-03-17    
Medline Journal Info:
Nlm Unique ID:  8703518     Medline TA:  J Korean Med Sci     Country:  KOREA    
Other Details:
Languages:  eng     Pagination:  33-7     Citation Subset:  IM    
Department of Pathology and Internal Medicine, College of Medicine, Seoul National University, Korea.
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MeSH Terms
Adenoma / metabolism*,  pathology
Graves Disease / metabolism*,  pathology
Staining and Labeling
Thyroglobulin / biosynthesis*
Thyroid Neoplasms / pathology
Thyroiditis, Autoimmune / metabolism*,  pathology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): J Korean Med Sci
Journal ID (pmc): jkms
ISSN: 1011-8934
ISSN: 1598-6357
Publisher: Korean Academy of Medical Sciences
Article Information
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Print publication date: Month: 3 Year: 1990
Volume: 5 Issue: 1
First Page: 33 Last Page: 37
ID: 3053723
PubMed Id: 1698387

Thyroglobulin synthesis of oxyphilic cells in various types of neoplastic and autoimmune thyroid diseases.
T. S. Hwang
J. S. Suh
Y. I. Kim
S. H. Park
B. Y. Cho
C. S. Koh
Department of Pathology and Internal Medicine, College of Medicine, Seoul National University, Korea.

Article Categories:
  • Research Article

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