Document Detail


Thymus-homing dendritic cells in central tolerance.
MedLine Citation:
PMID:  23616226     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Central tolerance is critical in establishing a peripheral T-cell repertoire purged of functional autoreactive T cells. One of the major requirements for effective central tolerance is the presentation of self and other innocuous antigens (Ags), including food, gut flora, or airway allergens, to developing T cells in the thymus. This seemingly challenging task can be mediated in some cases by ectopic expression of tissue-specific Ags by thymic epithelial cells or by entry of systemic blood-borne Ags into the thymus. More recently, thymic homing peripheral dendritic cells (DCs) have been proposed as cellular transporters of peripheral tissue-specific Ags or foreign innocuous Ags. The aim of this viewpoint is to discuss the three principal thymic DC populations and their trafficking properties in the context of central tolerance. We will first discuss the importance of peripheral DC trafficking to the thymus and then compare and contrast the three DC subsets. We will describe how they were characterized, describe their trafficking to and their microenvironmental positioning in the thymus, and discuss the functional consequence of thymic trafficking and localization on thymic selection events.
Authors:
Husein Hadeiba; Eugene C Butcher
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-05-18
Journal Detail:
Title:  European journal of immunology     Volume:  43     ISSN:  1521-4141     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-21     Completed Date:  2013-09-06     Revised Date:  2013-09-18    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1425-9     Citation Subset:  IM    
Copyright Information:
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. hadeiba@stanford.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigen Presentation
Autoantigens / immunology
Cell Differentiation
Cell Movement
Central Tolerance*
Clonal Selection, Antigen-Mediated
Dendritic Cells / immunology*
Humans
Organ Specificity
T-Lymphocytes / immunology*
Thymus Gland / immunology*
Grant Support
ID/Acronym/Agency:
AI047822/AI/NIAID NIH HHS; AI07290/AI/NIAID NIH HHS; AI093981/AI/NIAID NIH HHS; DK084647/DK/NIDDK NIH HHS; R01 AI047822/AI/NIAID NIH HHS; R01 AI093981/AI/NIAID NIH HHS; R01 DK084647/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Autoantigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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