Document Detail

Thymus-derived cell (T cell) activation by heterologous antigens as a replacement of specific immune T cells in the transfer of the secondary response to sheep erythrocytes.
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MedLine Citation:
PMID:  4626849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Spleen cells from LAF(1) mice hyperimmune to sheep erythrocytes (SE) lost their ability to transfer a secondary response to irradiated recipients after incubation with anti-theta and rabbit complement in vitro. Small numbers of specific immune cells even when taken 3 days after a primary SE injection reconstituted the direct and indirect plaque-forming cell responses. Larger numbers of cells sensitized to B. abortus (or keyhole limpet hemocyanin), and given together with the corresponding antigen, also partially reconstituted the ability to respond to SE. This property was mediated by theta-bearing cells and was interpreted as due to a nonspecific humoral factor liberated by specifically activated T cells and acting on B cell proliferation or maturation.
Authors:
J J Mond; T Takahashi; G J Thorbecke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  136     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1972 Oct 
Date Detail:
Created Date:  1972-10-25     Completed Date:  1972-10-25     Revised Date:  2010-09-13    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  715-21     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibody Formation*
Antigens, Heterophile*
Bone Marrow / immunology*
Bone Marrow Cells*
Brucella abortus / immunology
Complement System Proteins
Cytotoxicity Tests, Immunologic
Endotoxins
Erythrocytes / immunology
Escherichia coli / immunology
Hemagglutination Tests
Hemocyanin
Hemolytic Plaque Technique
Immune Sera
Immunity, Maternally-Acquired*
Immunization, Passive
Immunologic Memory
Mercaptoethanol / pharmacology
Mice
Radiation Chimera
Sheep / immunology
Spleen / cytology,  immunology
Thymus Gland / immunology*
Chemical
Reg. No./Substance:
0/Antigens, Heterophile; 0/Endotoxins; 0/Immune Sera; 60-24-2/Mercaptoethanol; 9007-36-7/Complement System Proteins; 9013-72-3/Hemocyanin
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Copyright © 1972 by The Rockefeller University Press
Received Day: 24 Month: 5 Year: 1972
Print publication date: Day: 1 Month: 10 Year: 1972
Volume: 136 Issue: 4
First Page: 715 Last Page: 721
ID: 2139276
PubMed Id: 4626849

THYMUS-DERIVED CELL (T CELL) ACTIVATION BY HETEROLOGOUS ANTIGENS AS A REPLACEMENT OF SPECIFIC IMMUNE T CELLS IN THE TRANSFER OF THE SECONDARY RESPONSE TO SHEEP ERYTHROCYTES
J. J. Mond
T. Takahashi
G. J. Thorbecke
From the Department of Pathology, New York University Medical Center, New York 10016


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