Document Detail

Thymosin beta4 and corneal wound healing: visions of the future.
MedLine Citation:
PMID:  20536468     Owner:  NLM     Status:  MEDLINE    
Persistent corneal epithelial defects and inflammation within the central cornea can directly distort visual acuity and may lead to permanent visual loss. Therefore, treatments with agents that enhance corneal reepithelialization and regulate the inflammatory response without the deleterious side effects of currently used agents such as corticosteroids would result in improved clinical outcome and would represent a major advance in the field. Despite much progress in the areas of corneal wound healing research, clinically available pharmacological therapies that can promote repair and limit the visual complications from persistent corneal wounds are severely limited and remains a major deficiency in the field. Prior studies from our laboratory have demonstrated the potent wound healing and anti-inflammatory effects of thymosin beta4 (Tbeta(4); Tbeta4) in numerous models of corneal injury. We are studying the mechanisms by which Tbeta(4) suppresses inflammation and promotes repair. Herein, we discuss some of our new basic scientific directions that may lead to the use of Tbeta(4) as a novel corneal wound healing and anti-inflammatory therapy.
Gabriel Sosne; Ping Qiu; Michelle Kurpakus-Wheater; Howard Matthew
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1194     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-06-11     Completed Date:  2010-07-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  190-8     Citation Subset:  IM    
Department of Ophthalmology and Anatomy, Wayne State University School of Medicine, Kresge Eye Institute, Detroit, Michigan, USA.
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MeSH Terms
Adrenal Cortex Hormones / pharmacology,  therapeutic use
Cornea / injuries*
Corneal Diseases / drug therapy*
Eye Injuries / drug therapy
Inflammation / therapy
Thymosin / pharmacology,  therapeutic use*
Wound Healing / drug effects*,  physiology
Reg. No./Substance:
0/Adrenal Cortex Hormones; 61512-21-8/Thymosin; 77591-33-4/thymosin beta(4)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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