| Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues. | |
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MedLine Citation:
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PMID: 16099219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Here, we review the biochemical and molecular properties of thymosin beta(4) (Tbeta(4)), the major actin-sequestering molecule in eukaryotic cells, and its key role in dermal- and corneal-wound healing. Tbeta(4) has several, novel, potential clinical applications in the repair and remodeling of ulcerated tissues and solid organs following hypoxic injuries, such as myocardial infarction and stroke. It might also have important repair functions in the pathophysiologic sequelae that are associated with actin toxicity and with septic shock, such as respiratory distress syndrome, multi-organ failure and severe tissue trauma. |
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Authors:
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Allan L Goldstein; Ewald Hannappel; Hynda K Kleinman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Trends in molecular medicine Volume: 11 ISSN: 1471-4914 ISO Abbreviation: Trends Mol Med Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-09-12 Completed Date: 2006-09-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100966035 Medline TA: Trends Mol Med Country: England |
Other Details:
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Languages: eng Pagination: 421-9 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine and Health Sciences, 2300 I. Street, NW, Washington, DC 20037, USA. bcmalg@gwumc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Actins
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metabolism* Amino Acid Sequence Animals Humans Molecular Sequence Data Neoplasms / metabolism Thymosin / chemistry, metabolism* Wound Healing / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Actins; 61512-21-8/Thymosin; 77591-33-4/thymosin beta(4) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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