Document Detail


Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues.
MedLine Citation:
PMID:  16099219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Here, we review the biochemical and molecular properties of thymosin beta(4) (Tbeta(4)), the major actin-sequestering molecule in eukaryotic cells, and its key role in dermal- and corneal-wound healing. Tbeta(4) has several, novel, potential clinical applications in the repair and remodeling of ulcerated tissues and solid organs following hypoxic injuries, such as myocardial infarction and stroke. It might also have important repair functions in the pathophysiologic sequelae that are associated with actin toxicity and with septic shock, such as respiratory distress syndrome, multi-organ failure and severe tissue trauma.
Authors:
Allan L Goldstein; Ewald Hannappel; Hynda K Kleinman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Trends in molecular medicine     Volume:  11     ISSN:  1471-4914     ISO Abbreviation:  Trends Mol Med     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-12     Completed Date:  2006-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100966035     Medline TA:  Trends Mol Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  421-9     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine and Health Sciences, 2300 I. Street, NW, Washington, DC 20037, USA. bcmalg@gwumc.edu
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MeSH Terms
Descriptor/Qualifier:
Actins / metabolism*
Amino Acid Sequence
Animals
Humans
Molecular Sequence Data
Neoplasms / metabolism
Thymosin / chemistry,  metabolism*
Wound Healing / physiology*
Chemical
Reg. No./Substance:
0/Actins; 61512-21-8/Thymosin; 77591-33-4/thymosin beta(4)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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