| Thymosin alpha 1 in combination with interferon alpha and ribavirin in chronic hepatitis C patients who are non-responders or relapsers to interferon alpha plus ribavirin. | |
| | |
MedLine Citation:
|
PMID: 15623184 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Interferon alpha (IFN-alpha) with or without ribavirin is an approved therapy for patients with chronic hepatitis C. However, a sustained response is achieved in less than 40% of all treated cases. Retreatment of relapsers or non-responders usually fails. Thymosin alpha 1 (Ta-1) is a polypeptide with immunomodulatory properties that has been suggested to increase response rates in patients with chronic hepatitis C. The aim of present study was to evaluate the efficacy of a novel triple regimen which includes Ta-1 for relapsers and non-responders to the combination of TA-1 and ribavirin. METHODS: In the present study, 11 patients who relapsed (n=5) or did not respond (n=6) to previous INF-alpha-based therapy were retreated with combination Ta-1, INF-alpha and ribavirin for 12 months, and followed up for a further six months. RESULTS: Four out of five relapsers had a sustained response. One of the non-responders cleared the HCV RNA during the post-treatment follow-up. Minor adverse effects were observed during treatment with this combination therapy and no dose reduction or discontinuations were needed. CONCLUSION: This data suggests that thymosin alpha 1 may add to the efficacy of INF-alpha plus ribavirin in the retreatment of relapsers or non-responders to previous INF-alpha-based hepatitis C therapy. |
| | |
Authors:
|
Z Abbas; S S Hamid; S Tabassum; W Jafri |
Related Documents
:
|
23306584 - Lower tidal volume strategy (≈3 ml/kg) combined with extracorporeal co(2) removal ve... 1953524 - Can the response to interferon treatment be predicted in patients with chronic active h... 2156764 - Topical treatment with human leukocyte interferon of hpv 16 infections associated with ... 19920524 - Glaucoma filtering surgery with interferon-alpha-2b. 12000814 - Long-term outcomes of immediate repair compared with surveillance of small abdominal ao... 1831864 - Innominate artery occlusive disease: surgical approach and long-term results. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: JPMA. The Journal of the Pakistan Medical Association Volume: 54 ISSN: 0030-9982 ISO Abbreviation: J Pak Med Assoc Publication Date: 2004 Nov |
Date Detail:
|
Created Date: 2004-12-29 Completed Date: 2005-02-01 Revised Date: 2008-02-12 |
Medline Journal Info:
|
Nlm Unique ID: 7501162 Medline TA: J Pak Med Assoc Country: Pakistan |
Other Details:
|
Languages: eng Pagination: 571-4 Citation Subset: IM |
Affiliation:
|
Department of Medicine, The Aga Khan University Hospital, Karachi. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adjuvants, Immunologic
/
therapeutic use* Adult Antiviral Agents / therapeutic use* Drug Therapy, Combination Female Hepatitis C, Chronic / drug therapy*, immunology Humans Interferon-alpha / therapeutic use* Male Middle Aged Retreatment Ribavirin / therapeutic use* Thymosin / analogs & derivatives*, therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Adjuvants, Immunologic; 0/Antiviral Agents; 0/Interferon-alpha; 0/thymalfasin; 36791-04-5/Ribavirin; 61512-21-8/Thymosin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Anaesthesia for surgical correction of scoliosis with spinal cord monitoring--a case series.
Next Document: Non-endoscopic parameters for the identification of esophageal varices in patients with chronic hepa...