Document Detail


Thymosin Beta 4 protects mice from monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy.
MedLine Citation:
PMID:  25412097     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Pulmonary hypertension (PH) is a progressive vascular disease of pulmonary arteries that impedes ejection of blood by the right ventricle. As a result there is an increase in pulmonary vascular resistance and pulmonary arterial pressure causing right ventricular hypertrophy (RVH) and RV failure. The pathology of PAH involves vascular cell remodeling including pulmonary arterial endothelial cell (PAEC) dysfunction and pulmonary arterial smooth muscle cell (PASMC) proliferation. Current therapies are limited to reverse the vascular remodeling. Investigating a key molecule is required for development of new therapeutic intervention. Thymosin beta-4 (Tβ4) is a ubiquitous G-actin sequestering protein with diverse biological function and promotes wound healing and modulates inflammatory responses. However, it remains unknown whether Tβ4 has any protective role in PH. The purpose of this study is to evaluate the whether Tβ4 can be used as a vascular-protective agent. In monocrotaline (MCT)-induced PH mouse model, we showed that mice treated with Tβ4 significantly attenuated the systolic pressure and RVH, compared to the MCT treated mice. Our data revealed for the first time that Tβ4 selectively targets Notch3-Col 3A-CTGF gene axis in preventing MCT-induced PH and RVH. Our study may provide pre-clinical evidence for Tβ4 and may consider as vasculo-protective agent for the treatment of PH induced RVH.
Authors:
Chuanyu Wei; Il-Kwon Kim; Li Li; Liling Wu; Sudhiranjan Gupta
Related Documents :
19380547 - Mdct pulmonary angiography evaluation of pulmonary embolism in children.
23705047 - The empty azygos fissure.
24642867 - A paracardiac mass on chest x-ray due to giant lad pseudoaneurysm.
11239337 - Cardiopulmonary rehabilitation and cancer rehabilitation. 3. pulmonary rehabilitation.
1829767 - Elaeophora schneideri in moose (alces alces) from colorado.
11788477 - Metalloproteinase inhibition and the response to angioplasty and stenting in atheroscle...
Publication Detail:
Type:  Journal Article     Date:  2014-11-20
Journal Detail:
Title:  PloS one     Volume:  9     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2014  
Date Detail:
Created Date:  2014-11-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e110598     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Factors associated with perforation related to diagnostic balloon-assisted enteroscopy: analysis of ...
Next Document:  Identification of Ser/Thr kinase and Forkhead Associated Domains in Mycobacterium ulcerans: Characte...