| Thymosin β4 and Cardiac Regeneration: Are We Missing a Beat? | |
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MedLine Citation:
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PMID: 22628110 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Epicardial resident stem cells are known to differentiate into cardiomyocytes during cardiac development, amongst other cell types. Whether epicardium-derived progenitor cells (EPDCs) retain this plasticity in the adult heart has been the topic of heated scientific debate. Priming with thymosin beta 4, a peptide which has been suggested to be critical for cardiac development and to have cardio-protective properties, was recently shown to induce differentiation of EPDCs into cardiomyocytes in a small animal model of myocardial infarction. This finding is in stark contrast to another recent study in which thymosin beta 4 treatment following myocardial infarction did not induce cardiomyocyte differentiation of EPDCs. While EPDCs seem to exhibit overall cardio-protective effects on the heart following myocardial infarction, they have not been shown to differentiate into cardiomyocytes in a clinically relevant setting. It will be important to understand why the ability of one therapeutic agent to induce cardiomyocyte differentiation of EPDCs seemingly depends on a single variable, i.e. the time of administration. Furthermore, in light of a recent report, it appears that thymosin beta 4 may be dispensable for cardiac development. |
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Authors:
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David C Gajzer; Jerome Balbin; Hina W Chaudhry |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-25 |
Journal Detail:
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Title: Stem cell reviews Volume: - ISSN: 1558-6804 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101255952 Medline TA: Stem Cell Rev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Cardiovascular Regenerative Medicine, Cardiovascular Research Center, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1030, New York, NY, 10029, USA, david.gajzer@mssm.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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