Document Detail


Thymopentin down-regulates both activity and expression of iNOS in blood cells of Sézary syndrome patients.
MedLine Citation:
PMID:  22721692     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
While thymopentin has been used for many years in the experimental treatment of Sézary syndrome (SS), a rare and very aggressive lymphoma, its mechanism of action is still not known. Herein we show that this peptide acts as an inhibitor of isolated iNOS and nNOS isoforms, and reduces iNOS protein/mRNA levels and iNOS activity in blood cells obtained from both healthy donors and SS patients. Similar results were obtained with TPN-2, the N(ω)-nitro analogue of the Arg-Lys motif present in thymopentin. Additional investigations are necessary to confirm the role and the relative importance of the two mechanisms of iNOS down-regulation in the therapeutic action of these peptides against SS.
Authors:
Antonia Patruno; Paolo Tosco; Emily Borretto; Sara Franceschelli; Paolo Amerio; Mirko Pesce; Stefano Guglielmo; Pietro Campiglia; Maria Grazia Bernengo; Roberta Fruttero
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-18
Journal Detail:
Title:  Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society     Volume:  -     ISSN:  1089-8611     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709307     Medline TA:  Nitric Oxide     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Affiliation:
Department of Medicine and Aging Science, University "G. d'Annunzio" of Chieti-Pescara, Via dei Vestini 31, 66013 Chieti (Italy).
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Consumption of takeaway and fast food in a deprived inner London Borough: are they associated with c...
Next Document:  Setting limits for acceptable change in sediment particle size composition following marine aggregat...