| Thymocytes are activated by toluene inhalation through the transcription factors NF-κB, STAT5 and NF-AT. | |
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MedLine Citation:
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PMID: 20981857 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Toluene has been extensively examined for effects on the central nervous system. To investigate the influence of low-level inhalation of toluene on the naive immune cells, male C3H/HeN mice were exposed to filtered air (control) and 50 ppm of toluene for 3 weeks. Low-level exposure resulted in (1) increased proliferation of thymocytes, (2) IL-2 production induced in thymocytes and (3) activation of the transcription factors NF-κB, STAT5 and NF-AT in thymocytes. These results suggest that thymocytes are sensitive cells and T cell activators are candidates for biomarkers for low-level exposure to toluene on naive immune cells. |
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Authors:
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Jiqin Liu; Yasuhiro Yoshida; Naoki Kunugita; Junko Noguchi; Tsutomu Sugiura; Ning Ding; Keiichi Arashidani; Hidekazu Fujimaki; Uki Yamashita |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied toxicology : JAT Volume: 30 ISSN: 1099-1263 ISO Abbreviation: J Appl Toxicol Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109495 Medline TA: J Appl Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 656-60 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Immunology, School of Medicine, University of Occupational and Environmental Health Japan, Kitakyushu 807-8555, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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