Document Detail


Thymidine and somatomedin-like activity of fetal pig sera: effect of fetal decapitation.
MedLine Citation:
PMID:  2210919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of fetal decapitation on porcine serum thymidine and somatomedin activity was studied. Fetal decapitation, at 45 d of gestation, did not alter body weight when compared to controls at 110 d of gestation. Thymidine activity, measured as 3H-thymidine incorporation into rat L6 myoblasts in response to test sera, did not differ between decapitated (D) and control (C) fetal pig sera. Thymidine activity of fetal sera was low when compared to a postnatal normal pig serum pool (NPS) and approximately equal to that of a postnatal hypophysectomized pig serum pool (HPS). Somatomedin-like activity, measured as 35S-sulfate uptake into 110 d fetal costal cartilage, was similar in D and C sera and was low when compared to NPS. Postnatal cartilage, but not fetal cartilage, responded greater to NPS than to HPS when measuring somatomedin activity. This indicates that fetal cartilage may be sensitive to different factors than postnatal pig cartilage. Thymidine activity and somatomedin-like activity were also low in maternal sera when compared to NPS. The concentration of insulin-like growth factor-I (IGF-I) was lower in D sera when compared to C sera (0.26 +/- 0.03 vs 0.62 +/- 0.09 U/ml, respectively, p less than 0.05). It is postulated that locally produced growth factors, compared to circulating growth factors, may be more important determinants controlling the rapid growth rate of the fetus.
Authors:
R H McCusker; D R Campion
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Growth, development, and aging : GDA     Volume:  54     ISSN:  1041-1232     ISO Abbreviation:  Growth Dev Aging     Publication Date:    1990 Spring-Summer
Date Detail:
Created Date:  1990-11-08     Completed Date:  1990-11-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8809704     Medline TA:  Growth Dev Aging     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  31-8     Citation Subset:  IM    
Affiliation:
Department of Foods and Nutrition, University of Georgia, Athens 30602.
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MeSH Terms
Descriptor/Qualifier:
Animals
Embryonic and Fetal Development / physiology
Female
Fetal Blood / metabolism*
Hypophysectomy
Pituitary Gland / physiology
Pregnancy
Somatomedins / metabolism*
Swine
Thymidine / blood*
Chemical
Reg. No./Substance:
0/Somatomedins; 50-89-5/Thymidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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