Document Detail


Thymidine kinase activity in serum of renal cell carcinoma patients is a useful prognostic marker.
MedLine Citation:
PMID:  19282758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is known that the concentration and activity of the DNA precursor enzyme thymidine kinase 1 (TK1) in serum is significantly elevated in patients with malignancies, as compared with levels in patients with benign tumours and those in healthy individuals. For the first time, the use of serum TK1 as a prognostic marker for patients with renal cell carcinoma (RCC) was examined. Serum TK1 protein (STK1p) concentration and serum TK1 activity (STK1a) were determined by a dot blot chemoluminescence assay and a radio enzyme assay, respectively. There was no correlation between STK1p and STK1a in the same sera from 27 RCC patients. Only one STK1p value as compared with 15 STK1a values was clearly above the cut-off values (2 pmol/l and 6 U/l, respectively) for healthy individuals. STK1a values did not correlate with the level of TK1 expression in tumour sections from the RCC patients, estimated by immunohistochemistry staining. However, there was a significant correlation between STK1a levels and the grade, stage and size of the RCC tumours. The discrepancy between the STK1p and the STK1a results is likely to be because of reduced ability of the TK1 antibody to recognize the STK1 in sera from RCC patients. We conclude that the activity of STK1 is a useful tool for evaluating the prognosis of patients with RCC.
Authors:
Pengcheng Luo; Ellen He; Staffan Eriksson; Ji Zhou; Guozhu Hu; Jie Zhang; Sven Skog
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)     Volume:  18     ISSN:  1473-5709     ISO Abbreviation:  Eur. J. Cancer Prev.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-03     Completed Date:  2009-08-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9300837     Medline TA:  Eur J Cancer Prev     Country:  England    
Other Details:
Languages:  eng     Pagination:  220-4     Citation Subset:  IM    
Affiliation:
Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Carcinoma, Renal Cell / enzymology*,  pathology
Case-Control Studies
Female
Humans
Immunoenzyme Techniques
Kidney Neoplasms / enzymology*,  pathology
Male
Middle Aged
Neoplasm Staging
Pilot Projects
Prognosis
Thymidine Kinase / blood*
Tumor Markers, Biological / blood*
Chemical
Reg. No./Substance:
0/Tumor Markers, Biological; EC 2.7.1.21/Thymidine Kinase; EC 2.7.1.21/thymidine kinase 1

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