| Thymic fatness and approaches to enhance thymopoietic fitness in aging. | |
| | |
MedLine Citation:
|
PMID: 20650623 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
With advancing age, the thymus undergoes striking fibrotic and fatty changes that culminate in its transformation into adipose tissue. As the thymus involutes, reduction in thymocytes and thymic epithelial cells precede the emergence of mature lipid-laden adipocytes. Dogma dictates that adipocytes are 'passive' cells that occupy non-epithelial thymic space or 'infiltrate' the non-cellular thymic niches. The provenance and purpose of ectopic thymic adipocytes during aging in an organ that is required for establishment and maintenance of T cell repertoire remains an unsolved puzzle. Nonetheless, tantalizing clues about elaborate reciprocal relationship between thymic fatness and thymopoietic fitness are emerging. Blocking or bypassing the route toward thymic adiposity may complement the approaches to rejuvenate thymopoiesis and immunity in elderly. |
| | |
Authors:
|
Vishwa Deep Dixit |
Related Documents
:
|
302943 - Sequential stages of human t lymphocyte differentiation. 12096893 - Phenylethanolamine n-methyl transferase expression in mouse thymus and spleen. 22079983 - Cutting edge: activation of virus-specific cd4 t cells throughout γ-herpesvirus latency. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Current opinion in immunology Volume: 22 ISSN: 1879-0372 ISO Abbreviation: Curr. Opin. Immunol. Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-08-16 Completed Date: 2010-11-12 Revised Date: 2011-08-03 |
Medline Journal Info:
|
Nlm Unique ID: 8900118 Medline TA: Curr Opin Immunol Country: England |
Other Details:
|
Languages: eng Pagination: 521-8 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Laboratory of Neuroendocrine-Immunology, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA. Vishwa.dixit@pbrc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adipocytes
/
cytology* Adipose Tissue / cytology* Aging / immunology* Humans T-Lymphocytes / physiology Thymus Gland / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
R01 AG031797-01/AG/NIA NIH HHS; R01-AG031797/AG/NIA NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Stem cells and the aging hematopoietic system.
Next Document: Generic, symptom based, exercise rehabilitation; integrating patients with COPD and heart failure.