| Thymic extension in the superior mediastinum in patients with thymic hyperplasia: potential cause of false-positive findings on 18F-FDG PET/CT. | |
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MedLine Citation:
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PMID: 17515398 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Although 18F-FDG PET/CT is now well established as an accurate method for the staging and restaging of various cancers, it is also well recognized that many false-positive results can occur. One such false-positive is activity within the superior extent of the thymus in the superior mediastinum. CONCLUSION: We reviewed all PET/CT examinations performed in children and young adults under the age of 20 years at our institution over a 2-month period. In 11 (12%) of the 93 examinations, activity was identified in the superior mediastinum of similar intensity to the thymus, which is consistent with activity within the superior thymic extension. In light of the increasing clinical use of FDG PET/CT for cancer imaging, it is important that nuclear medicine physicians and radiologists be aware of this phenomenon to avoid misdiagnosis or overstaging of disease. |
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Authors:
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Clare S Smith; Heiko Sch?der; Henry W D Yeung |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: AJR. American journal of roentgenology Volume: 188 ISSN: 1546-3141 ISO Abbreviation: AJR Am J Roentgenol Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-05-22 Completed Date: 2007-06-12 Revised Date: 2010-05-24 |
Medline Journal Info:
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Nlm Unique ID: 7708173 Medline TA: AJR Am J Roentgenol Country: United States |
Other Details:
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Languages: eng Pagination: 1716-21 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology/Nuclear Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. smithc@mskcc.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Child, Preschool False Positive Reactions Female Fluorodeoxyglucose F18 / diagnostic use* Humans Image Enhancement / methods Infant Infant, Newborn Male Mediastinum / radiography, radionuclide imaging Positron-Emission Tomography / methods* Radiopharmaceuticals / diagnostic use Reproducibility of Results Retrospective Studies Sensitivity and Specificity Subtraction Technique Thymus Gland / radiography*, radionuclide imaging* Thymus Neoplasms / diagnosis* Tomography, X-Ray Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
| Comments/Corrections | |
Comment In:
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AJR Am J Roentgenol. 2010 Jun;194(6):W537
[PMID:
20489074
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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