Document Detail

Thymic epithelial cell-derived supernatants sustain the maturation of human prothymocytes: involvement of interleukin 1 and CD23.
MedLine Citation:
PMID:  1717288     Owner:  NLM     Status:  MEDLINE    
During their development, human CD7+ lymphoid stem cells migrate into the thymus where, following intimate contact with thymic tissue, they proliferate and differentiate into functionally mature T lymphocytes. In this study, we investigated the effect of thymic epithelial cell-derived supernatants (TEC-SN) on early CD7+CD2-CD3- thymocytes. Our results indicate that TEC-SN are able to promote CD2 and CD3/TcR alpha/beta expression by CD7+ precursors. This activity correlated with soluble CD23 and interleukin 1 levels in TEC-SN. Furthermore, monoclonal antibodies to these cytokines decreased in vitro maturation of prothymocytes. Thus, in addition to cell-cell interactions, human TEC produce cytokines able to support early steps of thymocyte differentiation.
A H Dalloul; C Fourcade; P Debré; M D Mossalayi
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of immunology     Volume:  21     ISSN:  0014-2980     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1991-11-13     Completed Date:  1991-11-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  2633-6     Citation Subset:  IM    
Groupe d'Immuno-hématologie Moléculaire, CNRS URA 625, CHU Pitié-Salpêtrière, Paris, France.
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MeSH Terms
Antigens, CD / analysis,  physiology*
Antigens, CD7
Antigens, Differentiation, B-Lymphocyte / physiology*
Antigens, Differentiation, T-Lymphocyte / analysis
Cell Differentiation
Epithelial Cells
Interleukin-1 / physiology*
Lymphokines / physiology
Receptors, Fc / physiology*
Receptors, IgE
T-Lymphocytes / cytology*
Thymus Gland / cytology*
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD7; 0/Antigens, Differentiation, B-Lymphocyte; 0/Antigens, Differentiation, T-Lymphocyte; 0/Interleukin-1; 0/Lymphokines; 0/Receptors, Fc; 0/Receptors, IgE

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