Document Detail


Thymectomy is more effective than conservative treatment for myasthenia gravis regarding outcome and clinical improvement.
MedLine Citation:
PMID:  19303987     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Myasthenia gravis (MG) is an autoimmune disease with a tremendous impact on the quality of life. Controversies over which patients should be operated on because they may benefit most from thymectomy are still ongoing. The aim of this study was to report our long-term results of patients with MG with comparison of thymectomy and conservative treatment. METHODS: We report a series of 252 patients with MG. Survival data were generated. Patients were seen in the outpatient clinic, where a modified Osserman score and quality of life score were evaluated at the end of the follow-up period for all surviving patients. RESULTS: A total of 172 patients with MG were followed after thymectomy or with conservative treatment for a median time of 9.8 years. Patients who underwent thymectomy had significantly greater rates of remission and improvement compared with conservative treatment. Furthermore, they had a significantly greater survival. CONCLUSION: Currently, different effective modalities of treatment are available in patients with MG. In our long-term follow-up, thymectomy was superior to conservative treatment regarding overall survival, clinical improvement, and remission rate. Therefore, thymectomy should be considered strongly for all patients with generalized MG.
Authors:
Kai Bachmann; Doreen Burkhardt; Inken Schreiter; Jussuf Kaifi; Paulus Schurr; Christoph Busch; Gunther Thayssen; Jakob R Izbicki; Tim Strate
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Publication Detail:
Type:  Journal Article     Date:  2009-02-08
Journal Detail:
Title:  Surgery     Volume:  145     ISSN:  1532-7361     ISO Abbreviation:  Surgery     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-23     Completed Date:  2009-05-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  United States    
Other Details:
Languages:  eng     Pagination:  392-8     Citation Subset:  AIM; IM    
Affiliation:
Department of General, Visceral, and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Germany. k.bachmann@uke.uni-hamburg.de
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Child
Female
Germany / epidemiology
Humans
Male
Middle Aged
Myasthenia Gravis / diagnosis,  mortality,  surgery*
Quality of Life*
Thymectomy*
Treatment Outcome
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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