Document Detail

Thunberginols A, B, and F, new antiallergic and antimicrobial principles from hydrangeae dulcis folium.
MedLine Citation:
PMID:  1477932     Owner:  NLM     Status:  MEDLINE    
Six new antiallergic and antimicrobial principles, thunberginols A, B, C, D, E, and F, were isolated from Hydrangeae Dulcis Folium, the fermented and dried leaves of Hydrangea macrophylla SERINGE var. thunbergii MAKINO. The chemical structures of thunberginols A, B, and F have been determined on the basis of chemical and physiocochemical evidence. Thunberginols A, B, and F showed more potent antiallergic activity than phyllodulcin, hydrangenol, and AA-861 in the in vitro test using the Schults-Dale reaction in sensitized guinea pig bronchial muscle. Thunberginols A, B, and F also exhibited antimicrobial activity against oral bacteria.
M Yoshikawa; E Uchida; N Chatani; N Murakami; J Yamahara
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  40     ISSN:  0009-2363     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-02-08     Completed Date:  1993-02-08     Revised Date:  2010-05-07    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  3121-3     Citation Subset:  IM    
Kyoto Pharmaceutical University, Kyoto, Japan.
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MeSH Terms
Anti-Bacterial Agents / chemistry,  pharmacology*
Bacteroidaceae / drug effects*
Benzofurans / chemistry,  pharmacology*
Benzoquinones / pharmacology
Bronchoconstriction / drug effects*
Coumarins / chemistry,  pharmacology*
Guinea Pigs
Microbial Sensitivity Tests
Passive Cutaneous Anaphylaxis
Plant Extracts / chemistry,  pharmacology*
Plants, Medicinal*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Benzofurans; 0/Benzopyrans; 0/Benzoquinones; 0/Coumarins; 0/Isocoumarins; 0/Plant Extracts; 147666-80-6/thunberginol A; 147666-81-7/thunberginol B; 147666-82-8/thunberginol F; 480-46-6/phyllodulcin; 480-47-7/hydrangenol; 80809-81-0/2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone

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