| Thrombus formation by the application of thrombin to the outer surface of mouse mesenteric vein: comparison with the application of ADP. | |
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MedLine Citation:
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PMID: 4089838 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mesenteries of mice under anesthesia were stretched over an inverted microscope. A micropipette filled with solution containing various concentrations of ADP or thrombin was brought into contact with the outside of a mesenteric vein by micromanipulation, and then poured over the outer surface of the vein. Morphological characteristics of the thrombi and the time needed for thrombus formation were examined. Application of either thrombin or ADP to the adventitia of mesenteric veins caused thrombus formation. Although thrombi by application of ADP seemed to be anchored by direct adhesion of platelets to the exposed subendothelium, thrombi by application of thrombin seemed to be anchored by deposited fibrin. |
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Authors:
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K Hatanaka; M Minamiyama; S Takaichi; K Tanaka; H Ishibashi-Ueda; M Imakita; A Yamamoto |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Thrombosis research Volume: 40 ISSN: 0049-3848 ISO Abbreviation: Thromb. Res. Publication Date: 1985 Dec |
Date Detail:
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Created Date: 1986-02-24 Completed Date: 1986-02-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0326377 Medline TA: Thromb Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 731-43 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Diphosphate
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toxicity* Animals Male Mesenteric Veins / drug effects, pathology*, ultrastructure Mice Mice, Inbred C57BL Thrombin / physiology* Thrombosis / pathology* Videotape Recording |
| Chemical | |
Reg. No./Substance:
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58-64-0/Adenosine Diphosphate; EC 3.4.21.5/Thrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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