Document Detail

A thrombus susceptibility comparison of two pulsatile Penn State 50 cc left ventricular assist device designs.
MedLine Citation:
PMID:  22825798     Owner:  NLM     Status:  MEDLINE    
Left ventricular assist devices (LVADs) have proven successful as bridge to transplant devices for patients awaiting donor organs. While survival rates continue to increase, destination therapy remains hindered by thrombus formation within the device. Research has shown that thrombosis is correlated to the fluid dynamics within the device and may be a result of sustained shear rates below 500 s(-1) on the polyurethane blood sac used in the Penn State pulsatile LVAD. Particle image velocimetry is used to compare flow within two 50 cc LVAD designs to assess fluid patterns and quantify wall shear rates in regions known from in vivo studies to be susceptible to thrombus formation. The two designs differ in their front face geometry. The V-1 model has an outward-facing "dome" whereas the face of the V-2 model is flat. A thrombus susceptibility metric, which uses measured wall shear rates and exposure times, was applied to objectively compare pump designs over the entire cardiac cycle. For each design, there are regions where wall shear rates remained below 500 s(-1) for the entire cardiac cycle resulting in high thrombus susceptibility potential. Results of this study indicate that the V-2 device had an overall lower propensity for thrombus formation in the current region of interest.
Michael A Navitsky; Steven Deutsch; Keefe B Manning
Related Documents :
21881378 - Single-stage operation for giant substernal goiter with severe coronary artery disease.
12466788 - Myocardial ischemia in kawasaki disease: evaluation with dipyridamole stress technetium...
22089058 - Association of galectin-3 and fibrosis markers with long-term cardiovascular outcomes i...
15130888 - Vascular transfer of adenovirus is augmented by nitric oxide in the rat heart.
15842428 - Continuous st-segment monitoring of patients with right bundle branch block and suspici...
7103638 - Acute spontaneous failure of a porcine aortic valve.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2012-07-24
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  41     ISSN:  1573-9686     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-17     Completed Date:  2013-05-28     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4-16     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Equipment Design
Heart Ventricles
Heart-Assist Devices / adverse effects*
Pulsatile Flow
Thrombosis / etiology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A computational model of fibroblast growth factor-2 binding to endothelial cells under fluid flow.
Next Document:  Floating lipid bilayers: models for physics and biology.