Document Detail

Thrombus Formation Patterns in HeartMate II continuous-flow left ventricular assist devices: A multifactorial phenomenon involving Kounis syndrome?
MedLine Citation:
PMID:  24727540     Owner:  NLM     Status:  Publisher    
Metallic devices are increasingly used in contemporary cardiological practice. They include coronary stents, artificial cardiac valves, bioprostheses for trancatheter aortic valve replacement, closure devices for patent foramen ovale and atrial septal defects, pacemakers and defibrillators and left ventricular assist devices. Metals constitute the main components of these devices. Metal anions eluted from the components attached to circulating proteins can act as sensitizers able to induce hypersensitivity inflammation and thrombosis. Allergy to nickel occurs in up to one fourth of the population in several areas of the world and is the most frequent cause of allergic contact dermatitis. HeartMate II device is made from titanium with ruby bearing. Titanium metal ions from HeartMate II are eluted through the action of blood, saline, proteins, and mechanical stress that can induce hypersensitivity and immune dysfunctions rendering titanium no longer biologically inert. An unexpected high rate of thrombosis with substantial morbidity and mortality has been observed with the use of this device making the search of causality of thrombosis mandatory in order to predict and prevent this daunting complication. Although the cause of thrombosis seems to be multifactorial, careful history taking regarding hypersensitivities, monitoring of inflammatory mediators and lymphocyte transformation studies should be always performed in sensitive patients.
Nicholas G Kounis; George D Soufras; Periklis Davlouros; Grigorios Tsigkas; George Hahalis
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-4-10
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  -     ISSN:  1538-943X     ISO Abbreviation:  ASAIO J.     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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