Document Detail

Thromboxane synthesis inhibition reverses group B Streptococcus-induced pulmonary hypertension.
MedLine Citation:
PMID:  3297489     Owner:  NLM     Status:  MEDLINE    
Group B Streptococcus (GBS) sepsis in humans may cause the persistent pulmonary hypertension syndrome. Infusions of GBS in animals elevate pulmonary artery pressure (PAP) and resistance and are associated with elevated thromboxane levels. We investigated the hemodynamic effects of the specific thromboxane synthesis inhibitor, dazmegrel, in a piglet model of GBS-induced pulmonary hypertension. PAP rose from 22 +/- 6 to 42 +/- 11 (SD) mm Hg during infusion of heat-killed GBS; pulmonary vascular resistance increased from 1440 +/- 400 to 4000 +/- 1040 dyne X sec/cm5. No significant changes in cardiac output, mean arterial pressure, or left atrial pressure were noted. Treatment with 1 mg/kg of dazmegrel resulted in a rapid return of PAP and resistance to control values. No other hemodynamic effects of either bacteria or drug were observed despite continued infusion of GBS.
M N Tarpey; G B Graybar; R K Lyrene; G Godoy; J Oliver; B M Gray; J B Philips
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Critical care medicine     Volume:  15     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-07-31     Completed Date:  1987-07-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  644-7     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure
Cardiac Output
Hypertension, Pulmonary / etiology,  prevention & control*
Imidazoles / therapeutic use*
Pulmonary Artery / physiopathology
Sepsis / complications*
Streptococcal Infections / complications*
Streptococcus agalactiae
Thromboxane-A Synthase / antagonists & inhibitors*
Reg. No./Substance:
0/Imidazoles; 76894-77-4/dazmegrel; EC Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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