| Thromboxane-mediated alveolar responses to acute obstruction of the pulmonary vasculature. | |
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MedLine Citation:
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PMID: 9117035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the mechanisms responsible for the accelerated radioaerosol transalveolar clearance rates caused by acute balloon occlusion of the pulmonary arterial tree in dogs, the effects of vagal tone (n = 5) and prostaglandins (n = 21) including thromboxane were evaluated. In 15 animals, serial pulmonary arterial and aortic blood samples were acquired to evaluate pertinent metabolic products. Balloon occlusion of a localized arterial territory caused significant acceleration of technetium-99m diethylenetriamine pentaacetic acid (Tc-99m DTPA) clearance in the zone immediately distal to the occlusion (baseline clearance half-time 23.1 +/- 0/7 min versus 19.3 +/- 0.4 min, mean +/- SEM, p < 0.05). Vagotomy had no effect on occlusion-accelerated clearance. However, significant (p < 0.05) normalization did occur in the presence of indomethacin (21.9 +/- 0.4 min) and meclofenamic acid (20.4 +/- 0.5 min). Plasma values of thromboxane rose dramatically (pulmonary blood baseline 119 pg/ml to > 40,000 pg/ml) and transiently immediately after pulmonary vascular occlusion, and this rise was blunted significantly (peak pulmonary thromboxane B2 [TXB2] concentration = 668 pg/ml, p < 0.05) by meclofenamic acid. Significant normalization of local DTPA clearance rates also occurred in the presence of a thromboxane receptor blocker (n = 4), even when blood levels of thromboxane were elevated. Changes in transalveolar DTPA clearance rates after balloon occlusion of pulmonary arteries seem to a significant extent to be thromboxane-mediated. |
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Authors:
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A Mitra; S J Feinmark; P O Alderson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 155 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 1997 Mar |
Date Detail:
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Created Date: 1997-04-18 Completed Date: 1997-04-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 978-83 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, College of Physicians and Surgeons, Columbia-Presbyterian Medical Center, New York, New York 10032, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arterial Occlusive Diseases / physiopathology* Balloon Dilatation Dogs Meclofenamic Acid / pharmacology Pulmonary Alveoli / physiopathology* Pulmonary Artery* Radiopharmaceuticals / diagnostic use*, pharmacokinetics Technetium Tc 99m Pentetate / diagnostic use*, pharmacokinetics Thromboxane A2 / physiology Thromboxane B2 / physiology Thromboxanes / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 0/Thromboxanes; 54397-85-2/Thromboxane B2; 57576-52-0/Thromboxane A2; 644-62-2/Meclofenamic Acid; 65454-61-7/Technetium Tc 99m Pentetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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