Document Detail


Thromboxane biosynthesis and antagonism in humans.
MedLine Citation:
PMID:  2959047     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite the evanescence of TXA2 in biological fluids, recent developments promise to considerably enhance our insight into the role of this molecule in vivo. Clinical trials already suggest that it plays an important role in certain human diseases, such as unstable angina. Combined administration of TX antagonists and TX synthase inhibitors offers a theoretical advantage over aspirin which may ultimately justify their place in the therapy of vascular disease in humans.
Authors:
G A FitzGerald; D J Fitzgerald; J A Lawson; R Murray
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Advances in prostaglandin, thromboxane, and leukotriene research     Volume:  17A     ISSN:  0732-8141     ISO Abbreviation:  Adv. Prostaglandin Thromboxane Leukot. Res.     Publication Date:  1987  
Date Detail:
Created Date:  1987-11-19     Completed Date:  1987-11-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8211444     Medline TA:  Adv Prostaglandin Thromboxane Leukot Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  199-203     Citation Subset:  IM    
Affiliation:
Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee 37232.
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MeSH Terms
Descriptor/Qualifier:
Blood Platelets / drug effects,  metabolism
Cardiovascular Diseases / metabolism
Humans
Receptors, Prostaglandin / metabolism
Receptors, Thromboxane
Thromboxane A2 / antagonists & inhibitors*
Thromboxane B2 / biosynthesis*
Grant Support
ID/Acronym/Agency:
HD 17413/HD/NICHD NIH HHS; HL 30400/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Prostaglandin; 0/Receptors, Thromboxane; 54397-85-2/Thromboxane B2; 57576-52-0/Thromboxane A2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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