| Thromboxane biosynthesis and antagonism in humans. | |
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MedLine Citation:
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PMID: 2959047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite the evanescence of TXA2 in biological fluids, recent developments promise to considerably enhance our insight into the role of this molecule in vivo. Clinical trials already suggest that it plays an important role in certain human diseases, such as unstable angina. Combined administration of TX antagonists and TX synthase inhibitors offers a theoretical advantage over aspirin which may ultimately justify their place in the therapy of vascular disease in humans. |
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Authors:
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G A FitzGerald; D J Fitzgerald; J A Lawson; R Murray |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Advances in prostaglandin, thromboxane, and leukotriene research Volume: 17A ISSN: 0732-8141 ISO Abbreviation: Adv. Prostaglandin Thromboxane Leukot. Res. Publication Date: 1987 |
Date Detail:
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Created Date: 1987-11-19 Completed Date: 1987-11-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8211444 Medline TA: Adv Prostaglandin Thromboxane Leukot Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 199-203 Citation Subset: IM |
Affiliation:
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Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee 37232. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Platelets
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drug effects,
metabolism Cardiovascular Diseases / metabolism Humans Receptors, Prostaglandin / metabolism Receptors, Thromboxane Thromboxane A2 / antagonists & inhibitors* Thromboxane B2 / biosynthesis* |
| Grant Support | |
ID/Acronym/Agency:
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HD 17413/HD/NICHD NIH HHS; HL 30400/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Prostaglandin; 0/Receptors, Thromboxane; 54397-85-2/Thromboxane B2; 57576-52-0/Thromboxane A2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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