| Thromboxane A2 and prostacyclin do not modulate pulmonary hemodynamics during exercise in sheep. | |
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MedLine Citation:
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PMID: 3536839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to determine the role of thromboxane and prostacyclin in modulating pulmonary hemodynamics during maximal cardiopulmonary stress in the healthy lung. We studied 11 yearling sheep in paired studies during progressive maximal treadmill exercise with and without meclofenamate (n = 5), ibuprofen (n = 6), or UK38485 (n = 2). We also studied five sheep during hypoxia and hypoxic exercise, and six sheep during prolonged steady-state treadmill exercise for 45-60 min with and without drug treatment. We measured the metabolites of thromboxane A2 (thromboxane B2, TxB2) and prostacyclin (6-ketoprostaglandin F1 alpha, 6-keto-PGF1 alpha) in blood plasma and lung lymph in each protocol. We found that progressive exercise significantly reduced pulmonary vascular resistance but that cyclooxygenase or thromboxane synthesis blockade did not alter the change. Plasma TxB2 rose minimally but significantly during maximal exercise, but 6-keto-PGF1 alpha did not change. During continuous hypoxia, exercise reduced pulmonary vascular resistance nearly to base-line levels, but the degree of reduction was also unchanged by drug treatment. There were also no significant changes in lymph or plasma TxB2 or 6-keto-PGF1 alpha during 45-60 min of continuous moderate exercise. We conclude that neither TxB2 nor prostacyclin modulate pulmonary hemodynamics in the normal lung during maximal exercise, prolonged moderate exercise, or exercise-induced reductions in vascular resistance during hypoxia. |
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Authors:
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J H Newman; B J Butka; K L Brigham |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 61 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1986 Nov |
Date Detail:
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Created Date: 1987-01-16 Completed Date: 1987-01-16 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1706-11 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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6-Ketoprostaglandin F1 alpha
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blood,
metabolism Animals Anoxia / physiopathology Blood Pressure Cardiac Output Epoprostenol / physiology* Hemodynamics Ibuprofen / pharmacology Imidazoles / pharmacology Lung / blood supply*, drug effects, metabolism Lymph / metabolism Meclofenamic Acid / pharmacology Physical Exertion* Pulmonary Artery / physiology Sheep Thromboxane A2 / blood, metabolism, physiology* Vascular Resistance |
| Grant Support | |
ID/Acronym/Agency:
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HL-00705/HL/NHLBI NIH HHS; HL-07123/HL/NHLBI NIH HHS; HL-19153/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Imidazoles; 15687-27-1/Ibuprofen; 35121-78-9/Epoprostenol; 57576-52-0/Thromboxane A2; 58962-34-8/6-Ketoprostaglandin F1 alpha; 644-62-2/Meclofenamic Acid; 76894-77-4/dazmegrel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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