Document Detail


Thromboxane A2 in cardiovascular and renal disorders: is there a defined role for thromboxane receptor antagonists or thromboxane synthase inhibitors?
MedLine Citation:
PMID:  2534279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thromboxane (TX) A2 and the prostaglandin endoperoxides, PGG2 and PGH2, have a number of biological activities including contraction of vascular and bronchial smooth muscle, platelet secretion and aggregation, and lysis of cellular membranes. Activation of TXA2 receptors may have deleterious consequences in various pathophysiologies, including coronary thrombosis, myocardial infarction, hypertension and renal injury. In addition to cyclooxygenase inhibitors, TX receptor antagonists and TX synthase inhibitors are available as specific pharmacological tools to investigate the specific involvement of TXA2 and the prostaglandin endoperoxides in these conditions. Recent reports indicate that these agents may be useful to prevent coronary artery thrombosis, prevent coronary artery reocclusion following thrombolytic therapy, attenuate the sequelae of circulatory shock, and improve kidney function after renal injury. This review will discuss the specific involvement of TX in these disorders, and compare the efficacy of different pharmacological approaches to the manipulation of either TX formation or activity.
Authors:
E F Smith
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Eicosanoids     Volume:  2     ISSN:  0934-9820     ISO Abbreviation:  Eicosanoids     Publication Date:  1989  
Date Detail:
Created Date:  1990-05-01     Completed Date:  1990-05-01     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8906009     Medline TA:  Eicosanoids     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  199-212     Citation Subset:  IM    
Affiliation:
Smith Kline and French Laboratories, Department of Pharmacology, King of Prussia, PA 19406.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiovascular Diseases / physiopathology*
Humans
Kidney Diseases / physiopathology*
Receptors, Prostaglandin / drug effects,  physiology
Receptors, Thromboxane
Thromboxane A2 / pharmacology,  physiology*
Thromboxane-A Synthase / antagonists & inhibitors,  physiology
Chemical
Reg. No./Substance:
0/Receptors, Prostaglandin; 0/Receptors, Thromboxane; 57576-52-0/Thromboxane A2; EC 5.3.99.5/Thromboxane-A Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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