| Thromboxane A2 in cardiovascular and renal disorders: is there a defined role for thromboxane receptor antagonists or thromboxane synthase inhibitors? | |
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MedLine Citation:
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PMID: 2534279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thromboxane (TX) A2 and the prostaglandin endoperoxides, PGG2 and PGH2, have a number of biological activities including contraction of vascular and bronchial smooth muscle, platelet secretion and aggregation, and lysis of cellular membranes. Activation of TXA2 receptors may have deleterious consequences in various pathophysiologies, including coronary thrombosis, myocardial infarction, hypertension and renal injury. In addition to cyclooxygenase inhibitors, TX receptor antagonists and TX synthase inhibitors are available as specific pharmacological tools to investigate the specific involvement of TXA2 and the prostaglandin endoperoxides in these conditions. Recent reports indicate that these agents may be useful to prevent coronary artery thrombosis, prevent coronary artery reocclusion following thrombolytic therapy, attenuate the sequelae of circulatory shock, and improve kidney function after renal injury. This review will discuss the specific involvement of TX in these disorders, and compare the efficacy of different pharmacological approaches to the manipulation of either TX formation or activity. |
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Authors:
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E F Smith |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Eicosanoids Volume: 2 ISSN: 0934-9820 ISO Abbreviation: Eicosanoids Publication Date: 1989 |
Date Detail:
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Created Date: 1990-05-01 Completed Date: 1990-05-01 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8906009 Medline TA: Eicosanoids Country: GERMANY, EAST |
Other Details:
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Languages: eng Pagination: 199-212 Citation Subset: IM |
Affiliation:
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Smith Kline and French Laboratories, Department of Pharmacology, King of Prussia, PA 19406. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiovascular Diseases / physiopathology* Humans Kidney Diseases / physiopathology* Receptors, Prostaglandin / drug effects, physiology Receptors, Thromboxane Thromboxane A2 / pharmacology, physiology* Thromboxane-A Synthase / antagonists & inhibitors, physiology |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Prostaglandin; 0/Receptors, Thromboxane; 57576-52-0/Thromboxane A2; EC 5.3.99.5/Thromboxane-A Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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