| Thrombotic thrombocytopenic purpura and pregnancy: a case report and a review of the literature. | |
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MedLine Citation:
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PMID: 11976823 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thrombotic thrombocytopenic purpura (TTP) is a severe disorder affecting the microcirculation of multiple organ systems. Plasma therapy has significantly reduced the mortality rate. Infections, pregnancy, cancers, drugs, and surgery were frequently associated with the initial episodes and relapses. Women who are either pregnant or in the postpartum period make up 10-25% of TTP patients, suggesting the interrelationship between TTP and pregnancy. The introduction of aggressive treatment with plasma transfusion or plasmapheresis improved maternal and fetal survival rates. We describe a case of a first successful pregnancy concomitant to a late relapse of TTP, in which the identification of important risk factors for both TTP and pregnancy allowed us easier hematological and obstetrical management. Proposed guidelines for pregnancy-related TTP management and a brief review of current treatment options for this rare condition are also included. |
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Authors:
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A Proia; R Paesano; F Torcia; L Annino; S Capria; A Ferrari; G Ferrazza; E Pacifici; A Pantalissi; G Meloni |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2002-02-23 |
Journal Detail:
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Title: Annals of hematology Volume: 81 ISSN: 0939-5555 ISO Abbreviation: Ann. Hematol. Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-04-26 Completed Date: 2002-07-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9107334 Medline TA: Ann Hematol Country: Germany |
Other Details:
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Languages: eng Pagination: 210-4 Citation Subset: IM |
Affiliation:
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Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia, University La Sapienza, Rome, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aspirin / administration & dosage Disease Management Female Heparin / administration & dosage Humans Practice Guidelines as Topic Pregnancy Pregnancy Complications, Hematologic / diagnosis, drug therapy, prevention & control* Purpura, Thrombotic Thrombocytopenic / diagnosis, drug therapy, prevention & control* Recurrence Risk Factors |
| Chemical | |
Reg. No./Substance:
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50-78-2/Aspirin; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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