Document Detail

Thrombotic thrombocytopenic purpura and pregnancy: a case report and a review of the literature.
MedLine Citation:
PMID:  11976823     Owner:  NLM     Status:  MEDLINE    
Thrombotic thrombocytopenic purpura (TTP) is a severe disorder affecting the microcirculation of multiple organ systems. Plasma therapy has significantly reduced the mortality rate. Infections, pregnancy, cancers, drugs, and surgery were frequently associated with the initial episodes and relapses. Women who are either pregnant or in the postpartum period make up 10-25% of TTP patients, suggesting the interrelationship between TTP and pregnancy. The introduction of aggressive treatment with plasma transfusion or plasmapheresis improved maternal and fetal survival rates. We describe a case of a first successful pregnancy concomitant to a late relapse of TTP, in which the identification of important risk factors for both TTP and pregnancy allowed us easier hematological and obstetrical management. Proposed guidelines for pregnancy-related TTP management and a brief review of current treatment options for this rare condition are also included.
A Proia; R Paesano; F Torcia; L Annino; S Capria; A Ferrari; G Ferrazza; E Pacifici; A Pantalissi; G Meloni
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2002-02-23
Journal Detail:
Title:  Annals of hematology     Volume:  81     ISSN:  0939-5555     ISO Abbreviation:  Ann. Hematol.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-04-26     Completed Date:  2002-07-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9107334     Medline TA:  Ann Hematol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  210-4     Citation Subset:  IM    
Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia, University La Sapienza, Rome, Italy.
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MeSH Terms
Aspirin / administration & dosage
Disease Management
Heparin / administration & dosage
Practice Guidelines as Topic
Pregnancy Complications, Hematologic / diagnosis,  drug therapy,  prevention & control*
Purpura, Thrombotic Thrombocytopenic / diagnosis,  drug therapy,  prevention & control*
Risk Factors
Reg. No./Substance:
50-78-2/Aspirin; 9005-49-6/Heparin

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