Document Detail


Thrombotic thrombocytopenic purpura mimicking an acute meningoencephalitis.
MedLine Citation:
PMID:  21485766     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thrombotic thrombocytopenic purpura is a rare, threatening disease characterized by thrombocytopenia, microangiopathic haemolytic anaemia and organ dysfunction, e.g., neurological impairment and renal insufficiency. We describe a patient with neurological impairment mimicking a meningoencephalitis in whom a thorough clinical evaluation along with appropriate laboratory tests led us to identify an underlying thrombotic thrombocytopenic purpura. The successful outcome of this patient was based on plasma exchange and immunosuppressive treatment. Thrombotic thrombocytopenic purpura should be considered in the differential diagnosis of patients presenting with any neurological abnormalities, anaemia and unexplained thrombocytopenia.
Authors:
F Tovoli; R De Giorgio; A Fabbri; M Serra; G Caio; V Grasso; C Felicani; G Barbara; U Volta
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta clinica Belgica     Volume:  66     ISSN:  1784-3286     ISO Abbreviation:  Acta Clin Belg     Publication Date:    2011 Jan-Feb
Date Detail:
Created Date:  2011-04-13     Completed Date:  2011-05-24     Revised Date:  2014-03-18    
Medline Journal Info:
Nlm Unique ID:  0370306     Medline TA:  Acta Clin Belg     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  55-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
ADAM Proteins / blood
Acute Disease
Adult
Diagnosis, Differential
Female
Humans
Meningoencephalitis / diagnosis*
Plasma Exchange
Purpura, Thrombotic Thrombocytopenic / diagnosis*,  physiopathology,  therapy
Chemical
Reg. No./Substance:
EC 3.4.24.-/ADAM Proteins; EC 3.4.24.-/ADAMTS13 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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