| Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome and adult onset Still's disease: case report and review of the literature. | |
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MedLine Citation:
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PMID: 18427722 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP/HUS) is a multisystem disorder characterized by consumptive thrombocytopenia, microangiopathic hemolytic anemia, neurologic symptoms, renal function abnormalities, and fever. Coexistence of TTP/HUS and adult onset Still's disease (ASD) is extremely rare. We report the case of a 46-year-old woman who presented with fever, arthritis, myalgias, petechia on skin and confusion five years after the onset of ASD. Thrombocytopenia, renal failure, marked elevation lactate dehydrogenase, and red cell fragmentation on peripheral blood smear were observed. We made a diagnosis of TTP/HUS associated with ASD, according to physical examination and characteristic laboratory data. She recovered from the TTP/HUS following daily sessions of therapeutic plasma exchange with fresh frozen plasma replacement and glucocorticoid therapy. Awareness of the possible development of TTP/HUS in ASD is important for early diagnosis and treatment. |
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Authors:
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Mehmet Sayarlioglu; Hayriye Sayarlioglu; Mesut Ozkaya; Ozan Balakan; Mehmet Ali Ucar |
Publication Detail:
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Type: Case Reports; Journal Article; Review Date: 2008-04-22 |
Journal Detail:
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Title: Modern rheumatology / the Japan Rheumatism Association Volume: 18 ISSN: 1439-7595 ISO Abbreviation: Mod Rheumatol Publication Date: 2008 |
Date Detail:
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Created Date: 2008-08-06 Completed Date: 2009-01-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100959226 Medline TA: Mod Rheumatol Country: Japan |
Other Details:
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Languages: eng Pagination: 403-6 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Division of Rheumatology, Sutcu Imam University Medical Faculty, Kahramanmaras, Turkey. sayarli@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Hemolytic-Uremic Syndrome / complications*, therapy Humans Middle Aged Plasma Exchange Purpura, Thrombotic Thrombocytopenic / complications*, therapy Still's Disease, Adult-Onset / complications*, therapy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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