| Thrombotic stroke associated with the use of porcine factor VIII in a patient with acquired haemophilia. | |
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MedLine Citation:
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PMID: 11886466 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Porcine factor VIII (pFVIII), which is used to control bleeding in patients with congenital or acquired haemophilia who have high-titre neutralizing antibodies to human FVIII, is not known to increase the risk of arterial or venous thrombosis. We have recently encountered a patient with acquired haemophilia who developed a thrombotic left middle cerebral artery distribution stroke while being treated with pFVIII. To our knowledge, this is the first such reported thrombotic event. We speculate that platelet activation induced by pFVIII may have contributed to thrombosis and suggest that pFVIII be used with caution in elderly patients with pre-existing cardiovascular risk factors. |
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Authors:
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A A Ashrani; M T Reding; E W Greeno; A Shet; N S Key |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Haemophilia : the official journal of the World Federation of Hemophilia Volume: 8 ISSN: 1351-8216 ISO Abbreviation: Haemophilia Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2002-03-11 Completed Date: 2003-07-17 Revised Date: 2009-10-21 |
Medline Journal Info:
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Nlm Unique ID: 9442916 Medline TA: Haemophilia Country: England |
Other Details:
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Languages: eng Pagination: 56-8 Citation Subset: IM |
Affiliation:
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Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Animals Arthritis, Rheumatoid Autoantibodies / blood Autoimmune Diseases / complications, drug therapy, immunology Factor VIII / administration & dosage, adverse effects*, immunology Fatal Outcome Hemophilia A / complications*, drug therapy, immunology, pathology Humans Intracranial Thrombosis / chemically induced*, etiology Male Swine |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 9001-27-8/Factor VIII |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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