Document Detail


Thrombotic occlusion of the common carotid artery (CCA) in acute ischemic stroke treated with intravenous tissue plasminogen activator (TPA).
MedLine Citation:
PMID:  17250737     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although common carotid artery (CCA) occlusions are rare, acute clinical presentations vary from mild to devastating strokes primarily due to tandem occlusions in the intracranial arteries. Three patients with acute CCA occlusions were treated with systemic tissue plasminogen activator (TPA). Blood pressures were kept at the upper limits allowed with TPA therapy with fluid balance and the 'head-down' position. Recanalization occurred in intracranial vessels only. Marked early neurological improvement occurred in two of three patients. CCA occlusions should not be considered contra-indication to systemic thrombolysis.
Authors:
V K Sharma; G Tsivgoulis; A Y Lao; M Flaster; J L Frey; M D Malkoff; A V Alexandrov
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  14     ISSN:  1468-1331     ISO Abbreviation:  Eur. J. Neurol.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-25     Completed Date:  2007-02-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  237-40     Citation Subset:  IM    
Affiliation:
Department of Neurology, Barrow Neurological Institute, Phoenix, AZ 85013, USA. drvijay@singnet.com.sg
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Aged
Aged, 80 and over
Angiography, Digital Subtraction
Brain Ischemia / etiology*
Carotid Artery Thrombosis / complications*,  diagnosis,  drug therapy*
Carotid Artery, Common*
Cerebral Angiography
Female
Fibrinolytic Agents / therapeutic use*
Humans
Male
Nervous System / drug effects,  physiopathology
Recovery of Function
Stroke / etiology*,  physiopathology
Tissue Plasminogen Activator / therapeutic use*
Tomography, X-Ray Computed
Treatment Outcome
Ultrasonography, Doppler, Duplex
Chemical
Reg. No./Substance:
0/Fibrinolytic Agents; EC 3.4.21.68/Tissue Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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