Document Detail


Thrombotic microangiopathy associated with Streptococcus pneumoniae bacteremia: case report and review.
MedLine Citation:
PMID:  8110927     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thrombotic microangiopathy, a disease within the clinical spectrum of thrombotic thrombocytopenic purpura and hemolytic-uremic syndrome, was recognized in a previously healthy 50-year-old woman who presented with pneumococcal bacteremia complicated by thrombocytopenia, microangiopathic hemolytic anemia, renal failure, and disorientation. After treatment with plasma exchange and antibiotics, the patient's clinical condition improved. Discontinuation of plasma exchange resulted in a relapse of thrombocytopenia and microangiopathic hemolytic anemia that responded to reinitiation of this intervention. The production of the enzyme neuraminidase by Streptococcus pneumoniae is thought to contribute to the pathogenesis of the thrombotic process. Although pneumococcal infection has been associated with hemolytic-uremic syndrome in children, review of the literature on adults revealed only one such case (in a patient who had undergone splenectomy in the remote past). This report therefore documents an unusual complication of pneumococcal bacteremia in an immunocompetent adult.
Authors:
K A Myers; T J Marrie
Related Documents :
20083997 - Acquired, noncongenital thrombotic thrombocytopenic purpura in children and adolescents...
2807187 - Lymph node pathology in henoch-schönlein purpura.
16011437 - Shiga-toxigenic escherichia coli o157:h7 infections among livestock exhibitors and visi...
2984637 - Neurologic manifestations of schoenlein-henoch purpura: report of three cases and revie...
1890597 - The epidemiology of aids in the new york and california medicaid programs.
22149577 - Clarifications about linaclotide.
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  17     ISSN:  1058-4838     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-03-25     Completed Date:  1994-03-25     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1037-40     Citation Subset:  IM    
Affiliation:
Department of Medicine, Victoria General Hospital, Dalhousie University, Halifax, Nova Scotia, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anemia, Hemolytic / etiology,  therapy
Bacteremia / complications*
Female
Humans
Kidney Failure / etiology
Middle Aged
Plasma Exchange
Platelet Transfusion / contraindications
Pneumococcal Infections / complications*
Thrombocytopenia / etiology,  therapy
Thrombosis / etiology*,  therapy
Comments/Corrections
Comment In:
Clin Infect Dis. 1995 Mar;20(3):720-1   [PMID:  7756507 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Extraosseous epidural tuberculoma: case report and review.
Next Document:  Maternal/congenital syphilis in a large tertiary-care urban hospital.